生物種
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リソース名
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RRC ID
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タイトル
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ジャーナル
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公開日
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外部リンク
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ヒト・動物細胞
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KP4(RCB1005)
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77543
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LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models.
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Invest New Drugs |
2013-8-1 |
Pubmed
Full text
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ヒト・動物細胞
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NUGC-4(RCB1939)
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69450
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The novel VEGF receptor/MET-targeted kinase inhibitor TAS-115 has marked in vivo antitumor properties and a favorable tolerability profile.
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Mol Cancer Ther |
2013-12-1 |
Pubmed
Full text
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ヒト・動物細胞
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KP4(RCB1005)
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65155
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First-in-Man Phase I Trial of the Selective MET Inhibitor Tepotinib in Patients with Advanced Solid Tumors.
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Clin Cancer Res |
2020-3-15 |
Pubmed
Full text
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ヒト・動物細胞
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PC-9(RCB4455)
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65151
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Activation of KRAS Mediates Resistance to Targeted Therapy in MET Exon 14-mutant Non-small Cell Lung Cancer.
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Clin Cancer Res |
2019-2-15 |
Pubmed
Full text
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ヒト・動物細胞
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KP4(RCB1005)
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64303
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Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET.
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J Biol Chem |
2021-1-1 |
Pubmed
Full text
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ヒト・動物細胞
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MKN45(RCB1001)
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61988
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Regulation of MET kinase inhibitor resistance by copy number of MET in gastric carcinoma cells.
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Oncol Res |
2013-1-1 |
Pubmed
Full text
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ヒト・動物細胞
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MKN45(RCB1001)
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61696
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In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models.
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Mol Cancer Ther |
2016-7-1 |
Pubmed
Full text
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ヒト・動物細胞
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MKN45(RCB1001)
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61368
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Design, synthesis and molecular docking studies of some novel spiro[indoline-3, 4′-piperidine]-2-ones as potential c-Met inhibitors
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European Journal of Medicinal Chemistry |
2012-4-1 |
Pubmed
Full text
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ヒト・動物細胞
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HS-SY-II(RCB2231)
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52223
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Therapeutic potential of TAS-115 via c-MET and PDGFRα signal inhibition for synovial sarcoma.
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BMC Cancer |
2017-5-16 |
Pubmed
Full text
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ヒト・動物細胞
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GCIY(RCB0555)
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ECC12(RCB1009)
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KE-97(RCB1435)
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44956
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Saracatinib impairs the peritoneal dissemination of diffuse-type gastric carcinoma cells resistant to Met and fibroblast growth factor receptor inhibitors.
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Cancer Sci |
2014-5-1 |
Pubmed
Full text
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ヒト・動物細胞
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MRC-5
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44834
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Ability of the Met kinase inhibitor crizotinib and new generation EGFR inhibitors to overcome resistance to EGFR inhibitors.
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PLoS One |
2013-1-1 |
Pubmed
Full text
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ヒト・動物細胞
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KP4(RCB1005)
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44547
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Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent.
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Proc Natl Acad Sci U S A |
2013-8-6 |
Pubmed
Full text
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ヒト・動物細胞
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44453
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Indazoles as potential c-Met inhibitors: design, synthesis and molecular docking studies.
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Eur J Med Chem |
2013-7-1 |
Pubmed
Full text
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ヒト・動物細胞
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LoVo(RCB1639)
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HCT116(RCB2979)
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44369
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EMD 1214063 and EMD 1204831 constitute a new class of potent and highly selective c-Met inhibitors.
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Clin Cancer Res |
2013-6-1 |
Pubmed
Full text
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ヒト・動物細胞
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43556
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A preclinical algorithm of soluble surrogate biomarkers that correlate with therapeutic inhibition of the MET oncogene in gastric tumors.
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Int J Cancer |
2012-3-15 |
Pubmed
Full text
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ヒト・動物細胞
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38545
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Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks.
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Invest New Drugs |
2012-8-1 |
Pubmed
Full text
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ヒト・動物細胞
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38176
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Molecular predictors of sensitivity to the MET inhibitor PHA665752 in lung carcinoma cells.
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J Thorac Oncol |
2010-9-1 |
Pubmed
Full text
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ヒト・動物細胞
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StromaNKtert(RCB2350)
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36942
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Targeting the pro-survival protein MET with tivantinib (ARQ 197) inhibits growth of multiple myeloma cells.
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Neoplasia |
2015-3-1 |
Pubmed
Full text
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ヒト・動物細胞
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ACC-MESO-1(RCB2292)
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ACC-MESO-4(RCB2293)
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18908
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Inhibition of Met/HGF receptor and angiogenesis by NK4 leads to suppression of tumor growth and migration in malignant pleural mesothelioma.
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Int J Cancer |
2010-10-15 |
Pubmed
Full text
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ヒト・動物細胞
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MKN45(RCB1001)
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17609
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Antitumor activity of SNX-2112, a synthetic heat shock protein-90 inhibitor, in MET-amplified tumor cells with or without resistance to selective MET Inhibition.
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Clin Cancer Res |
2011-1-1 |
Pubmed
Full text
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