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  • 検索条件 : 絞込み (MeSH = Proto-Oncogene Proteins c-met / antagonists & inhibitors*)
生物種 リソース名 タイトル
ヒト・動物細胞 KP4(RCB1005) LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models.
ヒト・動物細胞 NUGC-4(RCB1939) The novel VEGF receptor/MET-targeted kinase inhibitor TAS-115 has marked in vivo antitumor properties and a favorable tolerability profile.
ヒト・動物細胞 KP4(RCB1005) First-in-Man Phase I Trial of the Selective MET Inhibitor Tepotinib in Patients with Advanced Solid Tumors.
ヒト・動物細胞 PC-9(RCB4455) Activation of KRAS Mediates Resistance to Targeted Therapy in MET Exon 14-mutant Non-small Cell Lung Cancer.
ヒト・動物細胞 KP4(RCB1005) Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET.
ヒト・動物細胞 MKN45(RCB1001) Regulation of MET kinase inhibitor resistance by copy number of MET in gastric carcinoma cells.
ヒト・動物細胞 MKN45(RCB1001) In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models.
ヒト・動物細胞 MKN45(RCB1001) Design, synthesis and molecular docking studies of some novel spiro[indoline-3, 4′-piperidine]-2-ones as potential c-Met inhibitors
ヒト・動物細胞 HS-SY-II(RCB2231) Therapeutic potential of TAS-115 via c-MET and PDGFRα signal inhibition for synovial sarcoma.
ヒト・動物細胞 GCIY(RCB0555) , ECC12(RCB1009) , KE-97(RCB1435) Saracatinib impairs the peritoneal dissemination of diffuse-type gastric carcinoma cells resistant to Met and fibroblast growth factor receptor inhibitors.
ヒト・動物細胞 MRC-5 Ability of the Met kinase inhibitor crizotinib and new generation EGFR inhibitors to overcome resistance to EGFR inhibitors.
ヒト・動物細胞 KP4(RCB1005) Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent.
ヒト・動物細胞 Indazoles as potential c-Met inhibitors: design, synthesis and molecular docking studies.
ヒト・動物細胞 LoVo(RCB1639) , HCT116(RCB2979) EMD 1214063 and EMD 1204831 constitute a new class of potent and highly selective c-Met inhibitors.
ヒト・動物細胞 A preclinical algorithm of soluble surrogate biomarkers that correlate with therapeutic inhibition of the MET oncogene in gastric tumors.
ヒト・動物細胞 Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks.
ヒト・動物細胞 Molecular predictors of sensitivity to the MET inhibitor PHA665752 in lung carcinoma cells.
ヒト・動物細胞 StromaNKtert(RCB2350) Targeting the pro-survival protein MET with tivantinib (ARQ 197) inhibits growth of multiple myeloma cells.
ヒト・動物細胞 ACC-MESO-1(RCB2292) , ACC-MESO-4(RCB2293) Inhibition of Met/HGF receptor and angiogenesis by NK4 leads to suppression of tumor growth and migration in malignant pleural mesothelioma.
ヒト・動物細胞 MKN45(RCB1001) Antitumor activity of SNX-2112, a synthetic heat shock protein-90 inhibitor, in MET-amplified tumor cells with or without resistance to selective MET Inhibition.