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  • Search Condition : Filter (MeSH = Pyrimidines / pharmacology*)
Species Resource Title
Human and Animal Cells WI-38(RCB0702) Imatinib mesylate inhibits the proliferation-stimulating effect of human lung cancer-associated stromal fibroblasts on lung cancer cells.
Human and Animal Cells PC-12(RCB0009) Dorsomorphin stimulates neurite outgrowth in PC12 cells via activation of a protein kinase A-dependent MEK-ERK1/2 signaling pathway.
Human and Animal Cells WI-38(RCB0702) A liquid crystal-related compound induces cell cycle arrest at the G2/M phase and apoptosis in the A549 human non-small cell lung cancer cell line.
Human and Animal Cells 293T(RCB2202) Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability.
Human and Animal Cells Btk^(-) DT40(RCB1468) Selinexor is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia.
Human and Animal Cells JHOC-5(RCB1520) , JHOC-7(RCB1688) , JHOC-9(RCB2226) , JHOM-1(RCB1676) , JHOS-3(RCB1546) Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition.
Human and Animal Cells Li-7(RCB1941) ASP5878, a Novel Inhibitor of FGFR1, 2, 3, and 4, Inhibits the Growth of FGF19-Expressing Hepatocellular Carcinoma.
Human and Animal Cells BOY-12E(RCB2627) , JMSU1(RCB2227) ASP5878, a selective FGFR inhibitor, to treat FGFR3-dependent urothelial cancer with or without chemoresistance.
Human and Animal Cells PC-9(RCB4455) Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.
Human and Animal Cells KP4(RCB1005) Translational pharmacokinetic-pharmacodynamic modeling of preclinical and clinical data of the oral MET inhibitor tepotinib to determine the recommended phase II dose.
Human and Animal Cells HuCCT1(RCB1960) , TFK-1(RCB2537) Inhibition of ATR Increases the Sensitivity to WEE1 Inhibitor in Biliary Tract Cancer.
Human and Animal Cells A549(RCB0098) The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo.
Human and Animal Cells 32Dcl3 Functional characterization, localization, and inhibitor sensitivity of the TPR-FGFR1 fusion in 8p11 myeloproliferative syndrome.
Human and Animal Cells CACO-2(RCB0988) Augmented pentose phosphate pathway plays critical roles in colorectal carcinomas.
Human and Animal Cells HCT116(RCB2979) , MKN45(RCB1001) Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1.
Human and Animal Cells RAW 264(RCB0535) Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis-associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects.
Human and Animal Cells 409B2(HPS0076) , 610B1(HPS0331) , 10T1/2(RCB0247) Isolation of induced pluripotent stem cell-derived endothelial progenitor cells from sac-like structures.
Human and Animal Cells StromaNKtert(RCB2350) Bruton's tyrosine kinase inhibition increases BCL-2 dependence and enhances sensitivity to venetoclax in chronic lymphocytic leukemia.
Human and Animal Cells PANC-1(RCB2095) Alternating magnetic field enhances cytotoxicity of Compound C.
Human and Animal Cells COLO-320(RCB1193) Dclk1 Inhibition Cancels 5-FU-induced Cell-cycle Arrest and Decreases Cell Survival in Colorectal Cancer.