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  • Search Condition : Filter (MeSH = Sirtuins / metabolism*)
Species Resource
Human and Animal Cells Inhibition of H3K18 deacetylation of Sirt7 by Myb-binding protein 1a (Mybbp1a).
Human and Animal Cells SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer.
C.elegans tm3223 Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol.
C.elegans tm1037 3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1.
Human and Animal Cells TE-4(RCB2097) , TE-8(RCB2098) , TE-9(RCB1988) , TE-11 (RCB2100) Downregulation of SIRT4 Expression Is Associated with Poor Prognosis in Esophageal Squamous Cell Carcinoma.
C.elegans NA C. elegans sirtuins.
C.elegans tm2648 , tm2673 Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases.
Prokaryotes E. coli Deacetylation of topoisomerase I is an important physiological function of E. coli CobB.
C.elegans tm2256 C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins.