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  • Search Condition : Filter (MeSH = Tumor Suppressor Protein p53 / metabolism*)
Species Resource
DNA material AxCANCre (RDB01748) Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells.
Mice p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation.
Zebrafish RIKEN WT (RW) , rw021 (Tg(ath5:GFP))? , rw255(piy)? Mutation of DNA primase causes extensive apoptosis of retinal neurons through the activation of DNA damage checkpoint and tumor suppressor p53.
Mice A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations.
Mice C3H/HeN-TgH(p53) p53-Mediated gene activation in mice at high doses of chronic low-dose-rate γ radiation.
Mice C3H/HeN-TgH(p53) Activation of interferon-stimulated genes by gamma-ray irradiation independently of the ataxia telangiectasia mutated-p53 pathway.
DNA material AxCAhp53WT (forward) (RDB02755) Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.
DNA material pp53-Box RE-TK hRluc(F) (RDB05593) RNF43 interacts with NEDL1 and regulates p53-mediated transcription.
Medaka HdrR-II1 (IB178) , Hd-rR-p53(y186x) (MT1166) , p53(y186x) (MT893) Gamma-ray irradiation promotes premature meiosis of spontaneously differentiating testis-ova in the testis of p53-deficient medaka (Oryzias latipes).
C.elegans The p53-like Protein CEP-1 Is Required for Meiotic Fidelity in C. elegans.
Mice C57BL-p53+/-(RBRC01361) Undifferentiated State Induced by Rb-p53 Double Inactivation in Mouse Thyroid Neuroendocrine Cells and Embryonic Fibroblasts.
C.elegans tm2427 , tm853 Stress-Induced Sleep After Exposure to Ultraviolet Light Is Promoted by p53 in Caenorhabditis elegans.
DNA material pCMV-VSV-G-RSV-Rev (RDB04393) , pCAG-HIVgp (RDB04394). PICT1 regulates TP53 via RPL11 and is involved in gastric cancer progression.
Mice B6.Cg-Trp53<tm1Sia>/Rbrc(RBRC01361) The Transcriptional Landscape of p53 Signalling Pathway.
DNA material CS-RfA-ETV (RDB08020) , CS-RfA-ETR (RDB08362) , CSII-EF-MCS-IRES2-hKO1 (RDB07915) , CSII-EF-MCS-IRES2-Venus (RDB04384) , CS-RfA-ETBsd (RDB07917) , pENTR4-H1tetOx1 (RDB07916). Genetic regulation of the RUNX transcription factor family has antitumor effects.
DNA material pGL3/hISCU_p53 BR (RDB14212) Regulation of iron homeostasis by the p53-ISCU pathway.
C.elegans tm853 Regulation of Caenorhabditis elegans p53/CEP-1-dependent germ cell apoptosis by Ras/MAPK signaling.
Mice C57BL-p53+/- Etoposide induces G2/M arrest and apoptosis in neural progenitor cells via DNA damage and an ATM/p53-related pathway.
DNA material pCAG-HIVgp (RDB04394) , pCMV-VSV-G-RSV-Rev (RDB04393) , CSII-CMV-MCS-IRES2-Bsd (RDB04385). Live-cell imaging visualizes frequent mitotic skipping during senescence-like growth arrest in mammary carcinoma cells exposed to ionizing radiation.
C.elegans BY4544 Depletion of a nucleolar protein activates xenobiotic detoxification genes in Caenorhabditis elegans via Nrf /SKN-1 and p53/CEP-1.