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  • Search Condition : Filter (MeSH = Tumor Suppressor Proteins / metabolism*)
Species Resource
C.elegans tm1231 RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.
Drosophila NP lines Cytoplasmic polyadenylation element binding protein is a conserved target of tumor suppressor HRPT2/CDC73.
Mice C3H/HeN-TgH(p53) Activation of interferon-stimulated genes by gamma-ray irradiation independently of the ataxia telangiectasia mutated-p53 pathway.
C.elegans tm1060 AMPH-1/Amphiphysin/Bin1 functions with RME-1/Ehd1 in endocytic recycling.
DNA material pENTR4-H1 (RDB04395) Bleomycin-induced over-replication involves sustained inhibition of mitotic entry through the ATM/ATR pathway.
Mice C57BL/6-TgN(a-CaMKII-nlCre)/20 (RBRC00254) Prox1 postmitotically defines dentate gyrus cells by specifying granule cell identity over CA3 pyramidal cell fate in the hippocampus.
DNA material pAxCALNLhIL-3R alpha(forward) (RDB04994) Opposing regulation of PROX1 by interleukin-3 receptor and NOTCH directs differential host cell fate reprogramming by Kaposi sarcoma herpes virus.
C.elegans Transdifferentiation mediated tumor suppression by the endoplasmic reticulum stress sensor IRE-1 in C. elegans.
Drosophila Tkv (YFP-Tkv) Lgd regulates the activity of the BMP/Dpp signalling pathway during Drosophila oogenesis.
Chicken / Quail Moloney murine leukemia virus integrase and reverse transcriptase interact with PML proteins.
Drosophila UAS-DEFL#6-1 , i.e. UAS-Ecadherin-GFP (DGRC#109005) The actin-binding protein profilin is required for germline stem cell maintenance and germ cell enclosure by somatic cyst cells.
C.elegans tm3886 , tm1145 Loss of Caenorhabditis elegans BRCA1 promotes genome stability during replication in smc-5 mutants.
DNA material CSII-CMV-MCS-IRES2-Bsd (RDB04385) , pCAG-HIVgp (RDB04394) , pCMV-VSV-G-RSV-Rev (RDB04393). Reduced level of the BCL11B protein is associated with adult T-cell leukemia/lymphoma.
DNA material pCMV-VSV-G-RSV-Rev (RDB04393) , pCAG-HIVgp (RDB04394). PICT1 regulates TP53 via RPL11 and is involved in gastric cancer progression.
Drosophila 10491R-2 The novel tumour suppressor Madm regulates stem cell competition in the Drosophila testis.
C.elegans tm764 , tm853 The Caenorhabditis elegans Werner syndrome protein functions upstream of ATR and ATM in response to DNA replication inhibition and double-strand DNA breaks.
DNA material AxCANCre (RDB01748) Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks.
Mice C57BL-p53+/- Etoposide induces G2/M arrest and apoptosis in neural progenitor cells via DNA damage and an ATM/p53-related pathway.
Zebrafish ? Vimentin regulates scribble activity by protecting it from proteasomal degradation.
DNA material pEF-BOSneoSE-mNotch2 RAMIC (RDB06772) Netrin-1-induced activation of Notch signaling mediates glioblastoma cell invasion.