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  • 検索条件 : 絞込み (MeSH = Ubiquitin-Protein Ligases / physiology*)
生物種 リソース名 タイトル
遺伝子材料 pMRX-IP-EGFP-mULK1 (RDB19624) Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy.
ヒト・動物細胞 Atg5^(+/+)MEF(RCB2710) , Atg5^(-/-)MEF(RCB2711) Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control.
ヒト・動物細胞 HuCCT1(RCB1960) FBXW7 suppresses epithelial-mesenchymal transition, stemness and metastatic potential of cholangiocarcinoma cells.
ショウジョウバエ 6190R-3 Drosophila Ube3a regulates monoamine synthesis by increasing GTP cyclohydrolase I activity via a non-ubiquitin ligase mechanism.
線虫 tm794 Molting-specific downregulation of C. elegans body-wall muscle attachment sites: the role of RNF-5 E3 ligase.
線虫 tm2321 The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons.
線虫 tm2957 , tm2975 PLR-1, a putative E3 ubiquitin ligase, controls cell polarity and axonal extensions in C. elegans.
ヒト・動物細胞 COLO 679(RCB0989) Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma.
ヒト・動物細胞 Role of recycling, Mindbomb1 association, and exclusion from lipid rafts of δ-like 4 for effective Notch signaling to drive T cell development.
遺伝子材料 AxCANCre (RDB01748) , AxCANLacZ (RDB01749). Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal.
ショウジョウバエ 1512R-3 , 11861R-2 , 31829R-2 insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila.
線虫 tm1743 , tm544 , tm659 , tm1173 , tm1380 , tm1180 ER E3 ubiquitin ligase HRD-1 and its specific partner chaperone BiP play important roles in ERAD and developmental growth in Caenorhabditis elegans.
線虫 tm1664 The C. elegans anaphase promoting complex and MBK-2/DYRK kinase act redundantly with CUL-3/MEL-26 ubiquitin ligase to degrade MEI-1 microtubule-severing activity after meiosis.