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  • Search Condition : Filter (MeSH = Ubiquitin-Protein Ligases / physiology*)
Species Resource Title
Mice RBRC01828 The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC.
DNA material pMRX-IP-EGFP-mULK1 (RDB19624) Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy.
Human and Animal Cells Atg5^(+/+)MEF(RCB2710) , Atg5^(-/-)MEF(RCB2711) Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control.
Human and Animal Cells HuCCT1(RCB1960) FBXW7 suppresses epithelial-mesenchymal transition, stemness and metastatic potential of cholangiocarcinoma cells.
Drosophila 6190R-3 Drosophila Ube3a regulates monoamine synthesis by increasing GTP cyclohydrolase I activity via a non-ubiquitin ligase mechanism.
C.elegans tm794 Molting-specific downregulation of C. elegans body-wall muscle attachment sites: the role of RNF-5 E3 ligase.
C.elegans tm2321 The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons.
C.elegans tm2957 , tm2975 PLR-1, a putative E3 ubiquitin ligase, controls cell polarity and axonal extensions in C. elegans.
Human and Animal Cells COLO 679(RCB0989) Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma.
Human and Animal Cells Role of recycling, Mindbomb1 association, and exclusion from lipid rafts of δ-like 4 for effective Notch signaling to drive T cell development.
DNA material AxCANCre (RDB01748) , AxCANLacZ (RDB01749). Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal.
Drosophila 1512R-3 , 11861R-2 , 31829R-2 insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila.
C.elegans tm1743 , tm544 , tm659 , tm1173 , tm1380 , tm1180 ER E3 ubiquitin ligase HRD-1 and its specific partner chaperone BiP play important roles in ERAD and developmental growth in Caenorhabditis elegans.
C.elegans tm1664 The C. elegans anaphase promoting complex and MBK-2/DYRK kinase act redundantly with CUL-3/MEL-26 ubiquitin ligase to degrade MEI-1 microtubule-severing activity after meiosis.