論文 - 詳細
| RRC ID | 12487 |
|---|---|
| 著者 | Germe T, Miller K, Cooper JP. |
| タイトル | A non-canonical function of topoisomerase II in disentangling dysfunctional telomeres. |
| ジャーナル | EMBO J |
| Abstract |
The decatenation activity of topoisomerase II (Top2), which is widely conserved within the eukaryotic domain, is essential for chromosomal segregation in mitosis. It is less clear, however, whether Top2 performs the same function uniformly across the whole genome, and whether all its functions rely on decatenation. In the fission yeast, Schizosaccharomyces pombe, telomeres are bound by Taz1, which promotes smooth replication fork progression through the repetitive telomeric sequences. Hence, replication forks stall at taz1 Delta telomeres. This leads to telomeric entanglements at low temperatures ( |
| 巻・号 | 28(18) |
| ページ | 2803-11 |
| 公開日 | 2009-9-16 |
| DOI | 10.1038/emboj.2009.223 |
| PII | emboj2009223 |
| PMID | 19680223 |
| PMC | PMC2750024 |
| MeSH | Alleles Catalysis Chromosomes / ultrastructure DNA / chemistry DNA Topoisomerases, Type II / chemistry* Dimerization Escherichia coli / metabolism Introns Mutagenesis, Site-Directed Mutation Point Mutation Protein Structure, Tertiary Schizosaccharomyces / enzymology* Schizosaccharomyces / genetics Telomere / ultrastructure* Temperature |
| IF | 9.889 |
| 引用数 | 30 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| 酵母 | |