| RRC ID |
36947
|
| 著者 |
Kato Y, Kamiya H, Koide N, Odkhuu E, Komatsu T, Watarai A, Kondo M, Kato K, Nakamura J, Yokochi T.
|
| タイトル |
Irbesartan attenuates production of high-mobility group box 1 in response to lipopolysaccharide via downregulation of interferon-β production.
|
| ジャーナル |
Int Immunopharmacol
|
| Abstract |
High-mobility group box 1 (HMGB1) is suggested to participate in development of local and systemic inflammatory disorders. Irbesartan (IRB), an angiotensin II type1 receptor blocker, is widely used for treatment of hypertension, especially in patients with diabetic nephropathy. The effect of IRB on lipopolysaccharide (LPS)-induced HMGB1 and nitric oxide (NO) production was examined using RAW 264.7 macrophage-like cells. IRB inhibited LPS-induced HMGB1 production. IRB also reduced LPS-induced expression of an inducible NO synthase, and inhibited LPS-induced NO production. The expression levels of IFN-β protein and mRNA, which is a key molecule in MyD88-independent pathway of LPS signaling, were exclusively inhibited by IRB. Peroxisome proliferator-activated receptor-γ and angiotensin II type 1 receptor were not involved in the inhibitory action of IRB on LPS-induced HMGB1 and NO production. Collectively, IRB was suggested to inhibit LPS-induced HMGB1 production via downregulation of IFN-β production in the MyD88-independent pathway.
|
| 巻・号 |
26(1)
|
| ページ |
97-102
|
| 公開日 |
2015-5-1
|
| DOI |
10.1016/j.intimp.2015.03.015
|
| PII |
S1567-5769(15)00109-5
|
| PMID |
25817178
|
| MeSH |
Animals
Anti-Inflammatory Agents / pharmacology*
Biphenyl Compounds / pharmacology*
Cell Culture Techniques
Cell Line
Cell Survival / drug effects
Down-Regulation
HMGB1 Protein / antagonists & inhibitors
HMGB1 Protein / biosynthesis*
Interferon-beta / antagonists & inhibitors
Interferon-beta / biosynthesis*
Irbesartan
Lipopolysaccharides / pharmacology*
Macrophages / drug effects*
Macrophages / immunology
Mice
Nitric Oxide / antagonists & inhibitors
Nitric Oxide / biosynthesis
Real-Time Polymerase Chain Reaction
Tetrazoles / pharmacology*
|
| IF |
3.943
|
| 引用数 |
0
|
|
WOS 分野
|
IMMUNOLOGY
PHARMACOLOGY & PHARMACY
|
| リソース情報 |
| ヒト・動物細胞 |
RAW 264(RCB0535) |
