論文 - 詳細
RRC ID | 36978 |
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著者 | Nishiwada S, Sho M, Yasuda S, Shimada K, Yamato I, Akahori T, Kinoshita S, Nagai M, Konishi N, Nakajima Y. |
タイトル | Clinical significance of CD155 expression in human pancreatic cancer. |
ジャーナル | Anticancer Res |
Abstract |
BACKGROUND/AIM:CD155 is expressed in many types of human cells and has diverse functions. We herein evaluated the clinical importance of CD155 in pancreatic cancer. MATERIALS AND METHODS:We investigated CD155 expression in 134 patients with pancreatic cancer, and evaluated the correlations of CD155 with prognosis, tumor immunity and angiogenesis. Furthermore, CD155 functions were examined. RESULTS:CD155 expression was abundant in pancreatic cancer tissues. Patients with high CD155 expression had poorer postoperative prognosis than those with low expression. Multivariate analysis indicated that CD155 expression had a significant independent prognostic value. Tumor CD155 expression inversely correlated with the presence of tumor-infiltrating lymphocytes. Furthermore, it significantly positively correlated with vascular endothelial growth factor expression and intra tumoral microvessel density. In addition, silencing of CD155 inhibited proliferation, and induced cell-cycle arrest at G2/M phase in pancreatic cancer cells. CONCLUSION:CD155 may play a critical role through both immunological and non-immuno logical mechanisms in pancreatic cancer and may be a therapeutic target for this intractable malignancy. |
巻・号 | 35(4) |
ページ | 2287-97 |
公開日 | 2015-4-1 |
PII | 35/4/2287 |
PMID | 25862891 |
MeSH | Aged Biomarkers, Tumor / biosynthesis* Biomarkers, Tumor / immunology Female Gene Expression Regulation, Neoplastic Humans Male Middle Aged Neoplasm Staging Neovascularization, Pathologic / genetics* Neovascularization, Pathologic / pathology Pancreatic Neoplasms / genetics* Pancreatic Neoplasms / immunology Pancreatic Neoplasms / pathology Prognosis Receptors, Virus / biosynthesis* Receptors, Virus / genetics Receptors, Virus / immunology Vascular Endothelial Growth Factor A / genetics |
IF | 1.994 |
引用数 | 47 |
WOS 分野 | ONCOLOGY |
リソース情報 | |
ヒト・動物細胞 | MIA Paca2(RCB2094) PANC-1(RCB2095) |