| RRC ID |
42318
|
| 著者 |
Nakamura H, Mukai M, Komatsu K, Tanaka-Okamoto M, Itoh Y, Ishizaki H, Tatsuta M, Inoue M, Miyoshi J.
|
| タイトル |
Transforming growth factor-beta1 induces LMO7 while enhancing the invasiveness of rat ascites hepatoma cells.
|
| ジャーナル |
Cancer Lett
|
| Abstract |
We have previously shown that transforming growth factor-beta1 (TGF-beta1) markedly stimulates the invasive capacity of rat ascites hepatoma AH130 W1 cells in vitro and in vivo. A differential hybridization procedure was used to isolate genes that were specifically up-regulated in TGF-beta1 treated W1 cells. Among ten independent cDNA clones, we focused on LMO7 and a variant isoform, LMO7S, that was generated by alternative splicing. LMO7 had PDZ and LIM domains, while LMO7S had only PDZ domain. TGF-beta1 up-regulated expression levels of LMO7 and LMO7S. LMO7 expression was up-regulated in the highly metastatic clone MM1.
|
| 巻・号 |
220(1)
|
| ページ |
95-9
|
| 公開日 |
2005-3-18
|
| DOI |
10.1016/j.canlet.2004.07.023
|
| PII |
S0304-3835(04)00574-9
|
| PMID |
15737692
|
| MeSH |
Animals
Ascites / metabolism
Carcinoma, Hepatocellular / metabolism*
Homeodomain Proteins / biosynthesis*
Liver Neoplasms / metabolism*
Neoplasm Invasiveness
Rats
Transcription Factors / biosynthesis*
Transforming Growth Factor beta / pharmacology*
Transforming Growth Factor beta1
Tumor Cells, Cultured
Up-Regulation
|
| IF |
7.36
|
| 引用数 |
15
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
Jyg-MC(A)(RCB0526)
Jyg-MC(B)(RCB0527) |
