| RRC ID |
44773
|
| 著者 |
Kamoshida G, Ogawa T, Oyanagi J, Sato H, Komiya E, Higashi S, Miyazaki K, Tsuji T.
|
| タイトル |
Modulation of matrix metalloproteinase-9 secretion from tumor-associated macrophage-like cells by proteolytically processed laminin-332 (laminin-5).
|
| ジャーナル |
Clin Exp Metastasis
|
| Abstract |
Macrophages infiltrating tumor tissues (tumor-associated macrophages, TAM) affect the malignant behaviors of tumor cells. We previously reported that monocytes were differentiated into TAM-like cells secreting matrix metalloproteinase (MMP)-9 by co-culture with tumor cells, and that cell adhesion to extracellular matrix (ECM) proteins played a critical role in the differentiation. In this study, we found that the monocyte differentiation was promoted by laminin-332 (laminin-5), a major epithelial ECM component. We also demonstrated that the proteolytic processing of the γ2 chain of laminin-332 was essential for its activity but that the N-terminal short arm of the γ2 chain inhibited MMP-9 secretion. These results indicate that the activity of laminin-332 for monocyte differentiation is dynamically regulated by the proteolytic processing of the γ2 chain.
|
| 巻・号 |
31(3)
|
| ページ |
285-91
|
| 公開日 |
2014-3-1
|
| DOI |
10.1007/s10585-013-9627-0
|
| PMID |
24292405
|
| MeSH |
Cell Adhesion
Cell Adhesion Molecules / chemistry
Cell Adhesion Molecules / genetics
Cell Adhesion Molecules / metabolism*
Cell Differentiation / genetics*
Cell Line, Tumor
Coculture Techniques
Extracellular Matrix Proteins / genetics
Extracellular Matrix Proteins / metabolism
Humans
Macrophages / metabolism
Matrix Metalloproteinase 9 / genetics
Matrix Metalloproteinase 9 / metabolism*
Monocytes / cytology*
Neoplasms / genetics
Neoplasms / pathology
|
| IF |
3.027
|
| 引用数 |
1
|
|
WOS 分野
|
ONCOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
MKN1(RCB1003) |
