RRC ID |
31030
|
著者 |
Gospodaryov DV, Lushchak OV, Rovenko BM, Perkhulyn NV, Gerards M, Tuomela T, Jacobs HT.
|
タイトル |
Ciona intestinalis NADH dehydrogenase NDX confers stress-resistance and extended lifespan on Drosophila.
|
ジャーナル |
Biochim Biophys Acta
|
Abstract |
An assembled cDNA coding for the putative single-subunit NADH dehydrogenase (NDX) of Ciona intestinalis was introduced into Drosophila melanogaster. The encoded protein was found to localize to mitochondria and to confer rotenone-insensitive substrate oxidation in organello. Transgenic flies exhibited increased resistance to menadione, starvation and temperature stress, and manifested a sex and diet-dependent increase in mean lifespan of 20-50%. However, NDX was able only weakly to complement the phenotypes produced by the knockdown of complex I subunits.
|
巻・号 |
1837(11)
|
ページ |
1861-1869
|
公開日 |
2014-11-1
|
DOI |
10.1016/j.bbabio.2014.08.001
|
PII |
S0005-2728(14)00561-1
|
PMID |
25124484
|
IF |
3.411
|
引用数 |
11
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
リソース情報 |
遺伝子材料 |
|
カタユウレイボヤ・(ニッポンウミシダ) |
Ciona intestinalis EST Clones
cibd016c12
ciad062k07
ciem809l11 |