論文 - 詳細
| RRC ID | 45510 |
|---|---|
| 著者 | Hasegawa Y, Kadota Y, Hasegawa C, Kawaminami S. |
| タイトル | Lignosulfonic Acid-Induced Inhibition of Intestinal Glucose Absorption. |
| ジャーナル | J Nutr Sci Vitaminol (Tokyo) |
| Abstract |
Lignosulfonic acid is a waste lignin produced from the sulfite pulping of softwood. We investigated the effect of lignosulfonic acid on α-glucosidase and found that lignosulfonic acid produced a reversible and non-competitive inhibition of the enzyme activity. Moreover, in human colorectal adenocarcinoma cells, lignosulfonic acid inhibited 2-deoxyglucose uptake, while in vivo studies demonstrated a significant reduction in the blood glycemic response to sucrose or glucose ingestion in rats treated with lignosulfonic acid. Feces of rats fed a diet supplemented with 5% lignosulfonic acid had higher sugar content compared to those of rats fed a control diet. These results suggest that lignosulfonic acid suppresses the rise in blood glucose levels through inhibition of α-glucosidase activity and intestinal glucose absorption. |
| 巻・号 | 61(6) |
| ページ | 449-54 |
| 公開日 | 2015-1-1 |
| DOI | 10.3177/jnsv.61.449 |
| PMID | 26875485 |
| MeSH | 3T3-L1 Cells Animals Blood Glucose / metabolism Caco-2 Cells Carbohydrate Metabolism / drug effects Cell Line, Tumor Colon / drug effects Colon / metabolism Deoxyglucose / metabolism Dietary Supplements Feces / chemistry Glucose / metabolism* Glycoside Hydrolase Inhibitors / pharmacology* Humans Industrial Waste Intestinal Absorption / drug effects* Intestinal Mucosa / metabolism Intestines / drug effects Lignin / pharmacology* Male Mice Plant Extracts / pharmacology* Rats, Wistar Sulfonic Acids / pharmacology* Wood / chemistry alpha-Glucosidases / metabolism* |
| IF | 1.424 |
| 引用数 | 9 |
| WOS 分野 | NUTRITION & DIETETICS |
| リソース情報 | |
| ヒト・動物細胞 | CACO-2(RCB0988) |