| RRC ID |
80864
|
| Author |
Wu X, Seida M, Abe T, Higashitani A.
|
| Title |
Mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial Ca2+ overload in Caenorhabditis elegans.
|
| Journal |
NPJ Aging
|
| Abstract |
Mitochonic acid-5 ameliorates the pathophysiology of human mitochondrial-disease fibroblasts and Caenorhabditis elegans Duchenne muscular dystrophy and Parkinson's disease models. Here, we found that 10 μM MA-5 attenuates the age-related decline in motor performance, loss of muscle mitochondria, and degeneration of dopaminergic neurons associated with mitochondrial Ca2+ overload in C. elegans. These findings suggest that MA-5 may act as an anti-aging agent against a wide range of neuromuscular dysfunctions in metazoans.
|
| Volume |
9(1)
|
| Pages |
20
|
| Published |
2023-8-1
|
| DOI |
10.1038/s41514-023-00116-2
|
| PII |
10.1038/s41514-023-00116-2
|
| PMID |
37528117
|
| PMC |
PMC10394014
|
| Resource |
| C.elegans |
tm1730
tm2366 |
