| RRC ID |
1006
|
| 著者 |
Oarada M, Tsuduki T, Suzuki T, Miyazawa T, Nikawa T, Hong-quan G, Kurita N.
|
| タイトル |
Dietary supplementation with docosahexaenoic acid, but not with eicosapentaenoic acid, reduces host resistance to fungal infection in mice.
|
| ジャーナル |
Biochim Biophys Acta
|
| Abstract |
The effect of dietary docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on host resistance to Paracoccidioides brasiliensis infection was investigated. Mice fed palm oil supplemented with DHA showed reduced antifungal activity in the spleen and liver, as compared with mice fed palm oil or soybean oil without supplementation with DHA. Mice fed DHA-supplemented soybean oil also showed reduced antifungal activity in the liver, but the extent of reduction was less profound. This reduction in antifungal activity was not observed with EPA-supplemented palm or EPA-supplemented soybean oil. These results suggest that two factors, DHA and palm oil in combination, are involved in reducing the host resistance. DHA-enriched palm oil was also responsible for an increase in DHA concentration and a marked decrease in arachidonic acid content in the spleen and liver. However, this group did not show elevated spleen and liver phospholipid hydroperoxide levels compared with the other groups, excluding the possibility that the reduction in antifungal activity observed with DHA-enriched palm oil is due to acceleration of in vivo lipid peroxidation. Greater infection-induced increases in spleen and serum interferon-gamma concentrations were observed in mice fed DHA-enriched palm oil compared with the other groups.
|
| 巻・号 |
1622(3)
|
| ページ |
151-60
|
| 公開日 |
2003-8-22
|
| DOI |
10.1016/s0304-4165(03)00136-3
|
| PII |
S0304416503001363
|
| PMID |
12928111
|
| MeSH |
Animals
Cytokines / biosynthesis
Dietary Supplements
Docosahexaenoic Acids / administration & dosage*
Docosahexaenoic Acids / analysis
Eicosapentaenoic Acid / administration & dosage*
Eicosapentaenoic Acid / analysis
Female
Immunity, Innate
Lipid Peroxidation
Liver / chemistry
Mice
Mice, Inbred BALB C
Organ Size
Paracoccidioidomycosis / immunology*
Phospholipids / metabolism
Spleen / chemistry
|
| IF |
3.411
|
| 引用数 |
16
|
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| 病原微生物 |
IFM 41621 |
