| RRC ID |
1021
|
| 著者 |
Shuaibu MN, Kanbara H, Yanagi T, Ichinose A, Ameh DA, Bonire JJ, Nok AJ.
|
| タイトル |
In vitro trypanocidal activity of dibutyltin dichloride and its fatty acid derivatives.
|
| ジャーナル |
Parasitol Res
|
| Abstract |
Searching for new compounds against pathogenic trypanosomes has been substantially accelerated by the development of in vitro screening assays. In an attempt to explore the chemotherapeutic potential of organotin compounds and to broaden the search for newer trypanocides, fatty acid derivatives of dibutyltin dichloride were synthesized and their in vitro trypanocidal profiles studied on Trypanosoma brucei brucei, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense. A 24-h time course experiment was conducted with various concentrations of the compounds using a 24-well microtiter plate technique. The compounds tested were trypanocidal in a dose-dependent fashion: inhibiting survival and growth, resulting in irreversible morphological deformation and the eventual death of the parasites. The minimum inhibitory concentrations of the tested diorganotins are at low micromolar ranges: from 0.15-0.75 microM for T. b. brucei, T. b. gambiense and T. b. rhodesiense. These observations suggest that organotin has chemotherapeutic potential.
|
| 巻・号 |
91(1)
|
| ページ |
5-11
|
| 公開日 |
2003-9-1
|
| DOI |
10.1007/s00436-003-0861-2
|
| PMID |
12851812
|
| MeSH |
Animals
Fatty Acids / chemistry*
Mice
Microscopy, Electron
Microscopy, Electron, Scanning
Organotin Compounds / chemistry
Organotin Compounds / pharmacology*
Parasitic Sensitivity Tests
Trypanocidal Agents / pharmacology*
Trypanosoma / drug effects*
Trypanosoma / growth & development
Trypanosoma / ultrastructure
Trypanosoma brucei brucei / drug effects
Trypanosoma brucei brucei / growth & development
Trypanosoma brucei brucei / ultrastructure
Trypanosoma brucei gambiense / drug effects
Trypanosoma brucei gambiense / growth & development
Trypanosoma brucei gambiense / ultrastructure
Trypanosoma brucei rhodesiense / drug effects
Trypanosoma brucei rhodesiense / growth & development
Trypanosoma brucei rhodesiense / ultrastructure
|
| IF |
1.641
|
| 引用数 |
15
|
|
WOS 分野
|
PARASITOLOGY
|
| リソース情報 |
| 病原微生物 |
T. b. brucei?
T. b. gambiense?
T. b. rhodesiense? |
