RRC ID 1043
Author Kageyama A, Hoshino Y, Watanabe M, Yazawa K, Mikami Y.
Title Clinical isolates of Nocardia brasiliensis from Japan exhibit variable susceptibility to the antibiotic imipenem.
Journal Mycopathologia
Abstract Clinical isolates of Nocardia brasiliensis from Japan were classified into two groups based on their susceptibility to the carbapenem antibiotic, imipenem (IPM). Of 33 strains tested, 10 belonged to an IPM susceptible group, with MIC of from 0.25 to 2 microg/ml and a MIC(80) value of 1.5 microg/ml for this antibiotic. The remaining 23 strains belonged to an IPM resistant group with MIC and MIC(80) values of 8-16 microg/ml and >16 microg/ml, respectively. The type strain of N. brasiliensis belonged to this resistant group. Analysis of 16S rDNA genes sequences showed that the IPM susceptible group had characteristic single nucleotide substitutions at positions 103 (T), 381 (A), and 456 (A), in contrast to the IPM resistant group. This grouping, however, was not associated with their clinical manifestation.
Volume 158(3)
Pages 275-8
Published 2004-10
DOI 10.1007/s11046-005-4487-z
PMID 15702268
MeSH Humans Imipenem / pharmacology* Japan Microbial Sensitivity Tests Nocardia / drug effects* Nocardia / genetics
IF 2.278
Times Cited 5
Pathogenic microorganisms N. brasiliensis?