RRC ID 1043
著者 Kageyama A, Hoshino Y, Watanabe M, Yazawa K, Mikami Y.
タイトル Clinical isolates of Nocardia brasiliensis from Japan exhibit variable susceptibility to the antibiotic imipenem.
ジャーナル Mycopathologia
Abstract Clinical isolates of Nocardia brasiliensis from Japan were classified into two groups based on their susceptibility to the carbapenem antibiotic, imipenem (IPM). Of 33 strains tested, 10 belonged to an IPM susceptible group, with MIC of from 0.25 to 2 microg/ml and a MIC(80) value of 1.5 microg/ml for this antibiotic. The remaining 23 strains belonged to an IPM resistant group with MIC and MIC(80) values of 8-16 microg/ml and >16 microg/ml, respectively. The type strain of N. brasiliensis belonged to this resistant group. Analysis of 16S rDNA genes sequences showed that the IPM susceptible group had characteristic single nucleotide substitutions at positions 103 (T), 381 (A), and 456 (A), in contrast to the IPM resistant group. This grouping, however, was not associated with their clinical manifestation.
巻・号 158(3)
ページ 275-8
公開日 2004-10-1
DOI 10.1007/s11046-005-4487-z
PMID 15702268
MeSH Humans Imipenem / pharmacology* Japan Microbial Sensitivity Tests Nocardia / drug effects* Nocardia / genetics
IF 2.452
引用数 6
WOS 分野 MYCOLOGY
リソース情報
病原微生物 N. brasiliensis?