Reference - Detail
RRC ID | 1051 |
---|---|
Author | Komatsu K, Tsuda M, Tanaka Y, Mikami Y, Kobayashi J. |
Title | Absolute stereochemistry of immunosuppressive macrolide brasilinolide A and its new congener brasilinolide C. |
Journal | J Org Chem |
Abstract |
Brasilinolide A (2) is a 32-membered polyhydroxyl macrolide with immunosuppressive activity isolated from a pathogenic actinomycete, Nocardia brasiliensis IFM0406. The absolute configurations at 26 chiral centers of 2 and its new congener, brasilinolide C (1), were determined on the basis of the spectral data of 1 and degradation products derived from 1 and 2. |
Volume | 69(5) |
Pages | 1535-41 |
Published | 2004-3-5 |
DOI | 10.1021/jo035773v |
PMID | 14987008 |
MeSH | Carbohydrate Conformation Hydrolysis Immunosuppressive Agents / chemistry* Immunosuppressive Agents / isolation & purification Macrolides / chemistry* Macrolides / isolation & purification Magnetic Resonance Spectroscopy Molecular Structure Nocardia / metabolism* Oxidation-Reduction Pyrans / chemistry* Pyrans / isolation & purification Stereoisomerism |
IF | 4.335 |
Times Cited | 24 |
WOS Category | CHEMISTRY, ORGANIC |
Resource | |
Pathogenic microorganisms | IFM 0406 |