論文 - 詳細
| RRC ID | 1055 |
|---|---|
| 著者 | Jones T, Federspiel NA, Chibana H, Dungan J, Kalman S, Magee BB, Newport G, Thorstenson YR, Agabian N, Magee PT, Davis RW, Scherer S. |
| タイトル | The diploid genome sequence of Candida albicans. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C. albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular analysis. We developed computational methods to assemble a diploid genome sequence in good agreement with available physical mapping data. We provide a whole-genome description of heterozygosity in the organism. Comparative genomic analyses provide important clues about the evolution of the species and its mechanisms of pathogenesis. |
| 巻・号 | 101(19) |
| ページ | 7329-34 |
| 公開日 | 2004-5-11 |
| DOI | 10.1073/pnas.0401648101 |
| PII | 0401648101 |
| PMID | 15123810 |
| PMC | PMC409918 |
| MeSH | Candida albicans / genetics* Diploidy* Genome, Fungal* Heterozygote |
| IF | 9.412 |
| 引用数 | 521 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| リソース情報 | |
| 病原微生物 | C. albicans? |