Reference - Detail
RRC ID | 1062 |
---|---|
Author | Ishikawa J, Yamashita A, Mikami Y, Hoshino Y, Kurita H, Hotta K, Shiba T, Hattori M. |
Title | The complete genomic sequence of Nocardia farcinica IFM 10152. |
Journal | Proc Natl Acad Sci U S A |
Abstract |
We determined the genomic sequence of Nocardia farcinica IFM 10152, a clinical isolate, and revealed the molecular basis of its versatility. The genome consists of a single circular chromosome of 6,021,225 bp with an average G+C content of 70.8% and two plasmids of 184,027 (pNF1) and 87,093 (pNF2) bp with average G+C contents of 67.2% and 68.4%, respectively. The chromosome encoded 5,674 putative protein-coding sequences, including many candidate genes for virulence and multidrug resistance as well as secondary metabolism. Analyses of paralogous protein families suggest that gene duplications have resulted in a bacterium that can survive not only in soil environments but also in animal tissues, resulting in disease. |
Volume | 101(41) |
Pages | 14925-30 |
Published | 2004-10-12 |
DOI | 10.1073/pnas.0406410101 |
PII | 0406410101 |
PMID | 15466710 |
PMC | PMC522048 |
MeSH | Amino Acid Sequence Chromosome Mapping Chromosomes, Bacterial / genetics Genome, Bacterial* Molecular Sequence Data Nocardia / genetics* RNA Polymerase II / genetics Sequence Alignment Sequence Homology, Amino Acid |
IF | 9.412 |
Times Cited | 206 |
WOS Category | MICROBIOLOGY |
Resource | |
Pathogenic microorganisms | IFM 10152 |