Reference - Detail
| RRC ID | 1064 |
|---|---|
| Author | Komatsu K, Tsuda M, Shiro M, Tanaka Y, Mikami Y, Kobayashi J. |
| Title | Brasilicardins B-D, new tricyclic terpenoids [correction of terpernoids] from actinomycete Nocardia brasiliensis. |
| Journal | Bioorg Med Chem |
| Abstract |
Three new tricyclic terpenoids, brasilicardins B-D (2-4), were isolated together with brasilicardin A (1), a potent immunosuppressive compound, from the cultured broth of a pathogenic actinomycete Nocardia brasiliensis IFM0406, and the structures and stereochemistry were determined by spectroscopic data and a single crystal X-ray diffraction analysis. The immunosuppressive and cytotoxic activities of 2-4 were examined in the comparison with 1. |
| Volume | 12(21) |
| Pages | 5545-51 |
| Published | 2004-11-1 |
| DOI | 10.1016/j.bmc.2004.08.007 |
| PII | S0968-0896(04)00610-8 |
| PMID | 15465331 |
| MeSH | Aminoglycosides / chemistry* Aminoglycosides / isolation & purification* Aminoglycosides / pharmacology Animals Cyclization Cytotoxins / chemistry Cytotoxins / isolation & purification Cytotoxins / pharmacology Female Immunosuppressive Agents / chemistry Immunosuppressive Agents / isolation & purification Immunosuppressive Agents / pharmacology Mice Mice, Inbred BALB C Mice, Inbred C57BL Nocardia / chemistry* Terpenes / chemistry* Terpenes / isolation & purification* Terpenes / pharmacology |
| IF | 3.073 |
| Times Cited | 21 |
| WOS Category | CHEMISTRY, ORGANIC CHEMISTRY, MEDICINAL BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Blogs |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Pathogenic microorganisms | IFM 0406 |