論文 - 詳細
RRC ID | 10738 |
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著者 | Li F, Awale S, Tezuka Y, Kadota S. |
タイトル | Cytotoxic constituents of propolis from Myanmar and their structure-activity relationship. |
ジャーナル | Biol Pharm Bull |
Abstract |
Thirteen cycloartane-type tritepenes (1-13) and four prenylated flavanones (14-17) isolated from propolis collected in Myanmar, were evaluated for their cytotoxic activity against a panel of six different cancer cell lines; three murine cancer cell lines (colon 26-L5 carcinoma, B16-BL6 melanoma, and Lewis lung carcinoma) and three human cancer cell lines (lung A549 adenocarcinoma, cervix HeLa adenocarcinoma and HT-1080 fibrosarcoma). Among them, a cycloartane-type triterpene, 3alpha,27-dihydroxycycloart-24E-en-26-oic acid (3), showed the most potent cytotoxicity against B16-BL6 cells with an IC(50) value of 5.91 microM, comparable to those of positive controls, doxorubicin (IC(50), 5.66 microM) and 5-fluorouracil (IC(50), 4.88 microM). In addition, (2S)-5,7-dihydroxy-4'-methoxy-8,3'-diprenylflavanone (14) exhibited strong cytotoxicity against all the tested cancer cell lines with the IC(50) values ranging from 14.0 to 26.4 microM. Based on the observed results, the structure-activity relationships are discussed. |
巻・号 | 32(12) |
ページ | 2075-8 |
公開日 | 2009-12-1 |
DOI | 10.1248/bpb.32.2075 |
PII | JST.JSTAGE/bpb/32.2075 |
PMID | 19952433 |
MeSH | Animals Antineoplastic Agents, Phytogenic / isolation & purification Antineoplastic Agents, Phytogenic / pharmacology Antineoplastic Agents, Phytogenic / therapeutic use* Apitherapy* Cell Line, Tumor Female Flavanones / isolation & purification Flavanones / pharmacology Flavanones / therapeutic use* Humans Inhibitory Concentration 50 Mice Myanmar Neoplasms / drug therapy* Prenylation Propolis / chemistry Propolis / pharmacology Propolis / therapeutic use* Structure-Activity Relationship Triterpenes / isolation & purification Triterpenes / pharmacology Triterpenes / therapeutic use* |
IF | 1.863 |
引用数 | 32 |
WOS 分野 | PHARMACOLOGY & PHARMACY |
リソース情報 | |
ヒト・動物細胞 | A549(RCB0098) HeLa(RCB0007) |