Reference - Detail
RRC ID | 10757 |
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Author | Awale S, Miyamoto T, Linn TZ, Li F, Win NN, Tezuka Y, Esumi H, Kadota S. |
Title | Cytotoxic constituents of Soymida febrifuga from Myanmar. |
Journal | J Nat Prod |
Abstract |
The 70% ethanol extract of Soymida febrifuga was found to kill PANC-1 human pancreatic cancer cells preferentially under nutrition-deprived conditions at a concentration of 10 microg/mL. Phytochemical investigation led to the isolation of 27 compounds including four new compounds [(3R)-6,4'-dihydroxy-8-methoxyhomoisoflavan (1), (2R)-7,4'-dihydroxy-5-methoxy-8-methylflavan (2), 7-hydroxy-6-methoxy-3-(4'-hydroxybenzyl)coumarin (3), and 6-hydroxy-7-methoxy-3-(4'-hydroxybenzyl)coumarin (4)]. 2',4'-Dihydroxychalcone (8) displayed the most potent preferential cytotoxicity (PC(50) 19.0 microM) against PANC-1 cells. In addition, the cytotoxic activity against colon 26-L5 carcinoma (colon 26-L5), B16-BL6 melanoma (B16-BL6), lung A549 adenocarcinoma (A549), cervix HeLa adenocarcinoma (HeLa), and HT-1080 fibrosarcoma (HT-1080) cell lines and their structure-activity relationship are discussed. The cytotoxic activity of 4'-hydroxy-3,5-dimethoxystilbene (6) against colon 26-L5 (IC(50) 2.96 microM) was found to be stronger than the positive control, doxorubicin, at IC(50) 3.12 microM. |
Volume | 72(9) |
Pages | 1631-6 |
Published | 2009-9-1 |
DOI | 10.1021/np9003323 |
PMID | 19689125 |
MeSH | Antineoplastic Agents, Phytogenic / chemistry Antineoplastic Agents, Phytogenic / isolation & purification* Antineoplastic Agents, Phytogenic / pharmacology* Coumarins / chemistry Coumarins / isolation & purification* Coumarins / pharmacology* Doxorubicin / pharmacology Drug Screening Assays, Antitumor Female HeLa Cells Humans Isoflavones / chemistry Isoflavones / isolation & purification* Isoflavones / pharmacology* Molecular Structure Myanmar Plant Bark / chemistry Stereoisomerism Stilbenes / chemistry Stilbenes / isolation & purification* Stilbenes / pharmacology* Structure-Activity Relationship |
IF | 3.782 |
Times Cited | 27 |
WOS Category | PHARMACOLOGY & PHARMACY PLANT SCIENCES CHEMISTRY, MEDICINAL |
Resource | |
Human and Animal Cells | A549(RCB0098) HeLa(RCB0007) |