論文 - 詳細
| RRC ID | 10761 |
|---|---|
| 著者 | Murata N, Murakami K, Ozawa Y, Kinoshita N, Irie K, Shirasawa T, Shimizu T. |
| タイトル | Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
Alzheimer's disease (AD) is characterized by progressive cognitive impairment and the formation of senile plaques. Silymarin, an extract of milk thistle, has long been used as a medicinal herb for liver diseases. Here we report marked suppression of amyloid β-protein (Aβ) fibril formation and neurotoxicity in PC12 cells after silymarin treatment in vitro. In vivo studies had indicated a significant reduction in brain Aβ deposition and improvement in behavioral abnormalities in amyloid precursor protein (APP) transgenic mice that had been preventively treated with a powdered diet containing 0.1% silymarin for 6 months. The silymarin-treated APP mice also showed less anxiety than the vehicle-treated APP mice. These behavioral changes were associated with a decline in Aβ oligomer production induced by silymarin intake. These results suggest that silymarin is a promising agent for the prevention of AD. |
| 巻・号 | 74(11) |
| ページ | 2299-306 |
| 公開日 | 2010-1-1 |
| DOI | 10.1271/bbb.100524 |
| PII | JST.JSTAGE/bbb/100524 |
| PMID | 21071836 |
| MeSH | Alzheimer Disease / drug therapy* Alzheimer Disease / prevention & control Animals Disease Models, Animal Mental Disorders / drug therapy* Mice Mice, Transgenic PC12 Cells Plaque, Amyloid / complications Plaque, Amyloid / drug therapy* Protective Agents Rats Silymarin / pharmacology* Silymarin / therapeutic use |
| IF | 1.516 |
| 引用数 | 39 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 15 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | PC-12(RCB0009) |