| RRC ID |
10761
|
| 著者 |
Murata N, Murakami K, Ozawa Y, Kinoshita N, Irie K, Shirasawa T, Shimizu T.
|
| タイトル |
Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model.
|
| ジャーナル |
Biosci Biotechnol Biochem
|
| Abstract |
Alzheimer's disease (AD) is characterized by progressive cognitive impairment and the formation of senile plaques. Silymarin, an extract of milk thistle, has long been used as a medicinal herb for liver diseases. Here we report marked suppression of amyloid β-protein (Aβ) fibril formation and neurotoxicity in PC12 cells after silymarin treatment in vitro. In vivo studies had indicated a significant reduction in brain Aβ deposition and improvement in behavioral abnormalities in amyloid precursor protein (APP) transgenic mice that had been preventively treated with a powdered diet containing 0.1% silymarin for 6 months. The silymarin-treated APP mice also showed less anxiety than the vehicle-treated APP mice. These behavioral changes were associated with a decline in Aβ oligomer production induced by silymarin intake. These results suggest that silymarin is a promising agent for the prevention of AD.
|
| 巻・号 |
74(11)
|
| ページ |
2299-306
|
| 公開日 |
2010-1-1
|
| DOI |
10.1271/bbb.100524
|
| PII |
JST.JSTAGE/bbb/100524
|
| PMID |
21071836
|
| MeSH |
Alzheimer Disease / drug therapy*
Alzheimer Disease / prevention & control
Animals
Disease Models, Animal
Mental Disorders / drug therapy*
Mice
Mice, Transgenic
PC12 Cells
Plaque, Amyloid / complications
Plaque, Amyloid / drug therapy*
Protective Agents
Rats
Silymarin / pharmacology*
Silymarin / therapeutic use
|
| IF |
1.516
|
| 引用数 |
39
|
|
WOS 分野
|
FOOD SCIENCE & TECHNOLOGY
CHEMISTRY, APPLIED
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
PC-12(RCB0009) |
