Reference - Detail
| RRC ID | 10808 |
|---|---|
| Author | Bazin MA, Le Lamer AC, Delcros JG, Rouaud I, Uriac P, Boustie J, Corbel JC, Tomasi S. |
| Title | Synthesis and cytotoxic activities of usnic acid derivatives. |
| Journal | Bioorg Med Chem |
| Abstract |
Nine usnic acid-amine conjugates were evaluated on murine and human cancer cell lines. The polyamine derivatives showed significant cytotoxicity in L1210 cells. Their activities appeared to be independent of the polyamine transport system (PTS). Indeed, their activities were similar in chinese hamster ovary (CHO) and in the PTS deficient CHO-MG cells. In addition, alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor known to indirectly enhance the activity of the PTS and consequently increase the cytotoxicity of cytotoxic drugs entering cells via the PTS, had no effect on the activity of the polyamine derivatives. The more active derivative (1,8-diaminooctane derivative) displayed similar activities on all cancer cell lines studied and induced apoptosis. |
| Volume | 16(14) |
| Pages | 6860-6 |
| Published | 2008-7-15 |
| DOI | 10.1016/j.bmc.2008.05.069 |
| PII | S0968-0896(08)00511-7 |
| PMID | 18558490 |
| MeSH | Animals Antineoplastic Agents / chemical synthesis Antineoplastic Agents / chemistry* Apoptosis / drug effects Benzofurans / chemical synthesis Benzofurans / chemistry* Benzofurans / pharmacology* CHO Cells Carrier Proteins Cell Line, Tumor Cricetinae Cricetulus Humans Mice Polyamines Structure-Activity Relationship |
| IF | 3.073 |
| Times Cited | 53 |
| WOS Category | CHEMISTRY, MEDICINAL CHEMISTRY, ORGANIC BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | U251(RCB0461) |