RRC ID 1083
Author Melo NR, Taguchi H, Jorge J, Pedro RJ, Almeida OP, Fukushima K, Nishimura K, Miyaji M.
Title Oral Candida flora from Brazilian human immunodeficiency virus-infected patients in the highly active antiretroviral therapy era.
Journal Mem Inst Oswaldo Cruz
Abstract One of the main opportunistic fungal infections amongst immunocompromised individuals is oral candidosis, which has been found in up to 90% of human immunodeficiency virus (HIV)-infected patients. This study employed yeasts isolated from the saliva and oral cavities of 114 HIV-infected patients living in Campinas, São Paulo. Of the isolates, 57.8% were identified as Candida albicans and 42.1% as non-C. albicans. The latter isolates were subsequently identified as C. krusei (7.5%), C. lusitaniae (5.2%), C. tropicalis (4.6%), C. parapsilosis (4.6%), C. glabrata (2.8%), C. kefyr (1.7%), C. guilliermondii (1.7%), C. intermedia (1.1%), C. norvegensis (0.5%), and Rhodotorula rubra (1.7%). Susceptibility of the isolates to amphotericin B, fluconazole, miconazole, and itraconazole was also determined by a microdilution method adopted by the National Committee for Clinical Laboratory Standards. The isolates demonstrated various susceptibilities to the antifungal agents. In particular 29 C. albicans and 13 non-C. albicans isolates showed low susceptibility to FLCZ (> 64 micro g/ml). This study revealed huge diversity of Candida species, in particular the increasing emergence of non-C. albicans associated with the oral flora of HIV-infected patients.
Volume 99(4)
Pages 425-31
Published 2004-6-1
DOI 10.1590/s0074-02762004000400014
PII S0074-02762004000400014
PMID 15322634
MeSH AIDS-Related Opportunistic Infections / microbiology* Antifungal Agents / pharmacology* Antiretroviral Therapy, Highly Active* Brazil Candida / classification* Candida / drug effects Candida / isolation & purification Candidiasis, Oral / microbiology* Case-Control Studies Female HIV Infections / drug therapy* HIV Infections / microbiology Humans Male Microbial Sensitivity Tests
IF 2.07
Times Cited 22
Pathogenic microorganisms Candida?