論文 - 詳細
| RRC ID | 10832 |
|---|---|
| 著者 | Fukasawa C, Ishiwada N, Ogita J, Hishiki H, Kohno Y. |
| タイトル | The effects of disodium cromoglycate on enhanced adherence of Haemophilus influenzae to A549 cells infected with respiratory syncytial virus. |
| ジャーナル | Pediatr Res |
| Abstract |
Nontypeable Haemophilus influenzae (NTHi) secondary infection often complicates respiratory syncytial virus (RSV) infections. Previous studies have revealed that RSV infections enhance NTHi adherence to airway epithelial cells. In this study, we investigated the effects of disodium cromoglycate (DSCG) and corticosteroids, which are frequently used for the treatment of wheezing often related to RSV infections, on the adherence of NTHi to RSV-infected A549 cells. DSCG inhibited enhanced adherence of NTHi to RSV-infected A549 cells, whereas dexamethasone (Dex) and fluticasone propionate (Fp) did not. DSCG suppressed the expression of ICAM-1, which is one of the NTHi receptors. Furthermore, DSCG exhibited an inhibitory effect on RSV infections. It is suggested that DSCG exerts an anti-RSV effect, and consequently attenuates the expression of NTHi receptors. |
| 巻・号 | 66(2) |
| ページ | 168-73 |
| 公開日 | 2009-8-1 |
| DOI | 10.1203/PDR.0b013e3181aa3b2e |
| PMID | 19390482 |
| MeSH | Androstadienes / pharmacology Androstadienes / therapeutic use Anti-Asthmatic Agents* / pharmacology Anti-Asthmatic Agents* / therapeutic use Bacterial Adhesion / drug effects* Bronchodilator Agents / pharmacology Bronchodilator Agents / therapeutic use Cell Line, Tumor Cromolyn Sodium* / pharmacology Cromolyn Sodium* / therapeutic use Dexamethasone / pharmacology Dexamethasone / therapeutic use Epithelial Cells / metabolism Epithelial Cells / virology Fluticasone Glucocorticoids / pharmacology Glucocorticoids / therapeutic use Haemophilus Infections / drug therapy* Haemophilus influenzae / drug effects* Humans Intercellular Adhesion Molecule-1 / metabolism Respiratory Mucosa / cytology Respiratory Syncytial Virus Infections / drug therapy* Respiratory Syncytial Viruses / drug effects* |
| IF | 2.747 |
| 引用数 | 3 |
| WOS 分野 | PEDIATRICS |
| リソース情報 | |
| ヒト・動物細胞 | A549(RCB0098) HEp-2(RCB1889) |