| RRC ID |
1092
|
| 著者 |
Hosoe T, Fukushima K, Itabashi T, Nozawa K, Takizawa K, Okada K, Takaki GM, Kawai K.
|
| タイトル |
A new nonadride derivative, dihydroepiheveadride, as characteristic antifungal agent against filamentous fungi, isolated from unidentified fungus IFM 52672.
|
| ジャーナル |
J Antibiot (Tokyo)
|
| Abstract |
In the screening of searching for new antifungal agents, a new nonaride compound, dihydroepiheveadride (1), was isolated from unidentified fungus IFM 52672 as the most potent antifungal principle from this organism. The structure of 1 was established on the basis of spectroscopic and chemical investigation, as well as detailed comparison of the spectroscopic and physico-chemical data of the oxidized derivative (3) from 1 with those of heveadride (2). Compound 1 showed strong antifungal activity against various filamentous fungi including human pathogens Aspergillus fumigatus, Penicillium marneffei and Trichophyton spp. It also showed the growth inhibition activity against certain human pathogenic yeasts such as Trichosporon species, while it had weak or no antifungal activity against Candida spp. and Cryptococcus neoformans, and no antibacterial activity against Bacillus subtilis nor against Escherichia coli. The antifungal potencies of compounds 2 and 3 were found to be weaker than that of 1.
|
| 巻・号 |
57(9)
|
| ページ |
573-8
|
| 公開日 |
2004-9-1
|
| DOI |
10.7164/antibiotics.57.573
|
| PMID |
15580958
|
| MeSH |
Anhydrides* / chemistry
Anhydrides* / isolation & purification
Anhydrides* / pharmacology
Antifungal Agents* / chemistry
Antifungal Agents* / isolation & purification
Antifungal Agents* / pharmacology
Bacteria / drug effects
Fungi / drug effects
Fungi / metabolism*
Heterocyclic Compounds, 3-Ring* / chemistry
Heterocyclic Compounds, 3-Ring* / isolation & purification
Heterocyclic Compounds, 3-Ring* / pharmacology
Humans
Maleic Anhydrides* / chemistry
Maleic Anhydrides* / isolation & purification
Maleic Anhydrides* / pharmacology
Microbial Sensitivity Tests
Structure-Activity Relationship
|
| IF |
2.668
|
| 引用数 |
13
|
|
WOS 分野
|
PHARMACOLOGY & PHARMACY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
IMMUNOLOGY
MICROBIOLOGY
|
| リソース情報 |
| 病原微生物 |
IFM 4808
IFM 4887
IFM 4928
IFM 5275
IFM 40210
IFM 40217
IFM 40951
IFM 41160
IFM 41243
IFM 41362
IFM 41398
41935
IFM 45108
IFM 45579
IFM 45802
IFM 46637
IFM 46798
IFM 46816
IFM 46823
IFM 46834
IFM 46863
IFM 46913
IFM 46921
IFM 46997
IFM 47078
IFM 48429
IFM 48608
IFM 52028
IFM 52672
IFM 52697
IFM 52703
IFM 52712
IFM 53787
IFM 53788
IFM 40009
IFM 41953 |
