論文 - 詳細
| RRC ID | 10954 |
|---|---|
| 著者 | Tsuji S, Tsuura Y, Morohoshi T, Shinohara T, Oshita F, Yamada K, Kameda Y, Ohtsu T, Nakamura Y, Miyagi Y. |
| タイトル | Secretion of intelectin-1 from malignant pleural mesothelioma into pleural effusion. |
| ジャーナル | Br J Cancer |
| Abstract |
BACKGROUND:Malignant pleural mesothelioma (MPM) is a rare but fatal tumour. Although most MPM patients show pleural effusion at even the early stage, it is hard to diagnose as MPM at the early stage because a sensitive and reliable diagnostic marker for MPM has not been found in plasma or pleural effusion. METHODS:In this study, we investigated whether intelectin-1 was specifically contained in MPM cells and the pleural effusion of MPM patient by immunohistochemistry, western blotting, and enzyme-linked immunosorbent assay. RESULTS:Malignant pleural mesothelioma cell lines, but not lung adenocarcinoma cell lines, secreted intelectin-1. In immunohistochemistry, epithelioid-type MPMs, but neither pleura-invading lung adenocarcinomas nor reactive mesothelial cells near the lung adenocarcinomas, were stained with anti-intelectin antibodies. Pleural effusion of MPM patients contained a higher concentration of intelectin-1 than that of lung cancer patients. CONCLUSION:These results suggest that detection of intelectin-1 may be useful for a differential diagnosis of epithelioid-type MPM in immunohistochemistry and that a high concentration of intelectin-1 in pleural effusion can be used as a new marker for clinical diagnosis of MPM. |
| 巻・号 | 103(4) |
| ページ | 517-23 |
| 公開日 | 2010-8-10 |
| DOI | 10.1038/sj.bjc.6605786 |
| PII | 6605786 |
| PMID | 20628387 |
| PMC | PMC2939784 |
| MeSH | Aged Biomarkers, Tumor / analysis Biomarkers, Tumor / metabolism* Cell Line, Tumor Cytokines / analysis Cytokines / metabolism* GPI-Linked Proteins Humans Lectins / analysis Lectins / metabolism* Male Mesothelioma / metabolism* Middle Aged Pleura / metabolism Pleural Effusion, Malignant / chemistry Pleural Effusion, Malignant / metabolism* Pleural Neoplasms / metabolism* |
| IF | 5.791 |
| 引用数 | 24 |
| WOS 分野 | ONCOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | ACC-MESO-1(RCB2292) ACC-MESO-4(RCB2293) A549(RCB0098) CACO-2(RCB0988) PC-3(RCB2145) DU145(RCB2143) |