| RRC ID |
10957
|
| Author |
Ishikawa T, Igarashi T, Hata K, Fujita T.
|
| Title |
c-fos induction by heat, arsenite, and cadmium is mediated by a heat shock element in its promoter.
|
| Journal |
Biochem Biophys Res Commun
|
| Abstract |
c-fos mRNA is induced by many types of noxious stimuli that are known to enhance transcription mediated by the heat shock element (HSE). Nonetheless, it has been accepted that the c-fos promoter does not contain an HSE. In this report, we revealed that the human and rodent c-fos promoters do contain HSEs which are highly responsive to heat, arsenite, and cadmium. These HSEs may play important roles in regulating c-fos expression in various pathological and physiological situations.
|
| Volume |
254(3)
|
| Pages |
566-71
|
| Published |
1999-1-27
|
| DOI |
10.1006/bbrc.1998.9979
|
| PII |
S0006-291X(98)99979-X
|
| PMID |
9920779
|
| MeSH |
Animals
Arsenites / pharmacology*
Base Sequence
Cadmium / pharmacology*
Cell Line
Cricetinae
DNA
Gene Expression Regulation* / drug effects
Genes, fos*
Heat-Shock Response*
Humans
Mice
Promoter Regions, Genetic*
RNA, Messenger / genetics
|
| Times Cited |
35
|
|
WOS Category
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Human and Animal Cells |
LLC(RCB0558) |
