Reference - Detail
| RRC ID | 10957 |
|---|---|
| Author | Ishikawa T, Igarashi T, Hata K, Fujita T. |
| Title | c-fos induction by heat, arsenite, and cadmium is mediated by a heat shock element in its promoter. |
| Journal | Biochem Biophys Res Commun |
| Abstract |
c-fos mRNA is induced by many types of noxious stimuli that are known to enhance transcription mediated by the heat shock element (HSE). Nonetheless, it has been accepted that the c-fos promoter does not contain an HSE. In this report, we revealed that the human and rodent c-fos promoters do contain HSEs which are highly responsive to heat, arsenite, and cadmium. These HSEs may play important roles in regulating c-fos expression in various pathological and physiological situations. |
| Volume | 254(3) |
| Pages | 566-71 |
| Published | 1999-1-27 |
| DOI | 10.1006/bbrc.1998.9979 |
| PII | S0006-291X(98)99979-X |
| PMID | 9920779 |
| MeSH | Animals Arsenites / pharmacology* Base Sequence Cadmium / pharmacology* Cell Line Cricetinae DNA Gene Expression Regulation* / drug effects Genes, fos* Heat-Shock Response* Humans Mice Promoter Regions, Genetic* RNA, Messenger / genetics |
| Times Cited | 35 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY |
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| Total number of mentions | 0 |
| Resource | |
| Human and Animal Cells | LLC(RCB0558) |