| RRC ID |
10978
|
| Author |
Cobb JA, Dunn AC, Kwon J, Sarntinoranont M, Sawyer WG, Tran-Son-Tay R.
|
| Title |
A novel method for low load friction testing on living cells.
|
| Journal |
Biotechnol Lett
|
| Abstract |
A low load tribology technique for studying the effects of friction on living cells was developed. Results show a direct relationship between the coefficient of friction (COF) and the extent of cell damage. The COF, mu, for a glass pin on an intact layer of human corneal epithelial cells is determined to be on the order of mu = 0.05 +/- 0.02 (n = 16). The correlations between applied normal load and extent of cell damage, as well as between number of reciprocation cycles and cell damage, are reported. It is also found that cell damage can occur when a loading force as low as 0.5 mN is applied, although the cells appear to be intact.
|
| Volume |
30(5)
|
| Pages |
801-6
|
| Published |
2008-5-1
|
| DOI |
10.1007/s10529-007-9623-z
|
| PMID |
18071637
|
| MeSH |
Cell Line
Cell Survival
Epithelial Cells / physiology*
Epithelium, Corneal / physiology*
Friction
Humans
Microscopy, Interference
Stress, Mechanical
|
| IF |
1.977
|
| Times Cited |
12
|
|
WOS Category
|
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
|
| Resource |
| Human and Animal Cells |
HCE-T(RCB2280) |
