Reference - Detail
| RRC ID | 10997 |
|---|---|
| Author | Tung NH, Ding Y, Choi EM, Van Kiem P, Van Minh C, Kim YH. |
| Title | New anthracene glycosides from Rhodomyrtus tomentosa stimulate osteoblastic differentiation of MC3T3-E1 cells. |
| Journal | Arch Pharm Res |
| Abstract |
Two new anthracene glycosides (1, 2) were isolated from aerial parts of Rhodomyrtus tomentosa, along with three known compounds (3-5). The structures of two new compounds were established to be 4,8,9,10-tetrahydroxy-2,3,7-trimethoxyanthracene-6-O-beta-D-glucopyranoside (1) and 2,4,7,8,9,10-hexahydroxy-3-methoxyanthracene-6-O-alpha-L-rhamnopyranoside (2) based on spectroscopic and chemical methods. Among them, compound 1, 2, and 5 significantly (P<0.05) increased the alkaline phosphatase activity, collagen synthesis, and mineralization of the nodules of MC3T3-E1 osteoblastic cells compared to those of the control, respectively. |
| Volume | 32(4) |
| Pages | 515-20 |
| Published | 2009-4-1 |
| DOI | 10.1007/s12272-009-1406-8 |
| PMID | 19407968 |
| MeSH | Alkaline Phosphatase / metabolism Animals Anthracenes / chemistry Anthracenes / isolation & purification Anthracenes / pharmacology* Calcification, Physiologic / drug effects Cell Differentiation / drug effects* Cell Line Collagen / metabolism Dose-Response Relationship, Drug Glycosides / chemistry Glycosides / isolation & purification Glycosides / pharmacology* Mice Mice, Inbred C57BL Molecular Structure Myrtaceae* / chemistry Osteoblasts / drug effects* Osteoblasts / metabolism Osteogenesis / drug effects* Plant Components, Aerial |
| IF | 2.934 |
| Times Cited | 13 |
| Resource | |
| Human and Animal Cells | MC3T3-E1(RCB1126) |