Reference - Detail
| RRC ID | 10998 |
|---|---|
| Author | Ding Y, Liang C, Yang SY, Ra JC, Choi EM, Kim JA, Kim YH. |
| Title | Phenolic compounds from Artemisia iwayomogi and their effects on osteoblastic MC3T3-E1 cells. |
| Journal | Biol Pharm Bull |
| Abstract |
One new (4) and twelve known phenolic compounds (1-3, 5-13) were isolated from a 70% MeOH extract of the aerial parts of Artemisia iwayomogi. The new compound was identified as 7,8-dimethoxy-coumarin-9-O-(6'-O-(E)-coumaroyl)-beta-D-glucopyranoside (4) and named iwayomin. The effects of compounds 1-13 on the function of osteoblastic MC3T3-E1 cells were examined by evaluating cell viability, alkaline phosphatase (ALP) activity, collagen synthesis, and mineralization in the presence of each compound. Compounds 3, 4, 7, and 9 showed potential in stimulating osteoblastic bone formation and may be useful for the prevention and/or treatment of osteoporosis. |
| Volume | 33(8) |
| Pages | 1448-53 |
| Published | 2010-1-1 |
| DOI | 10.1248/bpb.33.1448 |
| PII | JST.JSTAGE/bpb/33.1448 |
| PMID | 20686247 |
| MeSH | Alkaline Phosphatase / metabolism Animals Artemisia / chemistry* Calcium / metabolism Cell Line Cell Survival / drug effects Collagen / metabolism Magnetic Resonance Spectroscopy Mice Mice, Inbred C57BL Molecular Structure Osteoblasts / drug effects* Osteoblasts / enzymology Osteoporosis / prevention & control Phenols / isolation & purification Phenols / pharmacology* Plant Components, Aerial / chemistry Plant Extracts / isolation & purification Plant Extracts / pharmacology* Spectrometry, Mass, Electrospray Ionization |
| IF | 1.863 |
| Times Cited | 13 |
| WOS Category | PHARMACOLOGY & PHARMACY |
| Resource | |
| Human and Animal Cells | MC3T3-E1(RCB1126) |