RRC ID |
11
|
Author |
Morohashi T, Iwabuchi K, Watano K, Dashtsoodol N, Mishima T, Nakai Y, Shimada S, Nishida R, Fujii S, Onoé K.
|
Title |
Allograft inflammatory factor-1 regulates trinitrobenzene sulphonic acid-induced colitis.
|
Journal |
Immunology
|
Abstract |
The expression of allograft inflammatory factor-1 (AIF-1) in 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis, a model for T helper 1 (Th1) type disease, was investigated in BALB/c mice. The AIF-1 expression was significantly increased in the colitis lesion compared to that in the normal colon. We then prepared AIF-1 transgenic mice (Tgm) with the BALB/c background that express high levels of AIF-1 in lymphoid tissues and the colon. When AIF-1 Tgm were administrated TNBS, the TNBS-induced colitis was ameliorated compared with that in non-transgenic littermates. The amelioration of colitis was associated with the low expression of interleukin-1beta in the colon. The present findings suggest that AIF-1 regulates Th1-type inflammatory responses.
|
Volume |
110(1)
|
Pages |
112-9
|
Published |
2003-9-1
|
DOI |
10.1046/j.1365-2567.2003.01714.x
|
PII |
1714
|
PMID |
12941148
|
PMC |
PMC1783026
|
MeSH |
Animals
Calcium-Binding Proteins / genetics
Calcium-Binding Proteins / physiology*
Colitis / chemically induced
Colitis / immunology*
Colitis / pathology
Colon / immunology
Colon / metabolism
Cytokines / biosynthesis
Female
Gene Expression
Interleukin-1 / biosynthesis
Mice
Mice, Inbred BALB C
Mice, Transgenic
Microfilament Proteins
RNA, Messenger / genetics
Reverse Transcriptase Polymerase Chain Reaction
Th1 Cells / immunology
Trinitrobenzenesulfonic Acid
|
IF |
5.016
|
Times Cited |
19
|
WOS Category
|
IMMUNOLOGY
|
Resource |
Mice |
RBRC00471 |