Author Morohashi T, Iwabuchi K, Watano K, Dashtsoodol N, Mishima T, Nakai Y, Shimada S, Nishida R, Fujii S, Onoé K.
Title Allograft inflammatory factor-1 regulates trinitrobenzene sulphonic acid-induced colitis.
Journal Immunology
Abstract The expression of allograft inflammatory factor-1 (AIF-1) in 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis, a model for T helper 1 (Th1) type disease, was investigated in BALB/c mice. The AIF-1 expression was significantly increased in the colitis lesion compared to that in the normal colon. We then prepared AIF-1 transgenic mice (Tgm) with the BALB/c background that express high levels of AIF-1 in lymphoid tissues and the colon. When AIF-1 Tgm were administrated TNBS, the TNBS-induced colitis was ameliorated compared with that in non-transgenic littermates. The amelioration of colitis was associated with the low expression of interleukin-1beta in the colon. The present findings suggest that AIF-1 regulates Th1-type inflammatory responses.
Volume 110(1)
Pages 112-9
Published 2003-9-1
DOI 10.1046/j.1365-2567.2003.01714.x
PII 1714
PMID 12941148
PMC PMC1783026
MeSH Animals Calcium-Binding Proteins / genetics Calcium-Binding Proteins / physiology* Colitis / chemically induced Colitis / immunology* Colitis / pathology Colon / immunology Colon / metabolism Cytokines / biosynthesis Female Gene Expression Interleukin-1 / biosynthesis Mice Mice, Inbred BALB C Mice, Transgenic Microfilament Proteins RNA, Messenger / genetics Reverse Transcriptase Polymerase Chain Reaction Th1 Cells / immunology Trinitrobenzenesulfonic Acid
IF 5.016
Times Cited 19
Mice RBRC00471