論文 - 詳細
| RRC ID | 11000 |
|---|---|
| 著者 | Van Kiem P, Quang TH, Huong TT, Nhung le TH, Cuong NX, Van Minh C, Choi EM, Kim YH. |
| タイトル | Chemical constituents of Acanthus ilicifolius L. and effect on osteoblastic MC3T3E1 cells. |
| ジャーナル | Arch Pharm Res |
| Abstract |
A new coumaric acid derivative called acancifoliuside (1) and six known compounds as acteoside (2), isoacteoside (3), acanthaminoside (4), (+)-lyoniresinol 3a-O-beta-glucopyranoside (5), (-)-lyoniresinol (6), and alpha-amyrin (7), were isolated from the methanolic extract of the leaves of Acanthus ilicifolius L. (Acanthaceae). Their structures were determined by spectroscopic methods and a comparison with the spectral data reported in the literature. The effects of the compounds on the function of osteoblastic MC3T3-E1 cells were tested. Compounds 2, 3, and 5 (30 microM) increased the growth and differentiation of osteoblasts significantly (P<0.05), indicating that A. ilicifolius leaves may help prevent osteoporosis. |
| 巻・号 | 31(7) |
| ページ | 823-9 |
| 公開日 | 2008-7-1 |
| DOI | 10.1007/s12272-001-1232-3 |
| PMID | 18704321 |
| MeSH | 3T3 Cells Acanthaceae / chemistry* Alkaline Phosphatase / metabolism Animals Bone Density Conservation Agents / pharmacology* Calcium / metabolism Cell Differentiation / drug effects Chemical Phenomena Chemistry, Physical Collagen / metabolism Hydrolysis Magnetic Resonance Spectroscopy Mass Spectrometry Mice Molecular Conformation Osteoblasts / drug effects* Osteoblasts / enzymology Plant Extracts / chemistry Plant Extracts / pharmacology Plant Leaves / chemistry Spectrophotometry, Infrared Tetrazolium Salts Thiazoles |
| IF | 2.934 |
| 引用数 | 14 |
| WOS 分野 | PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |