論文 - 詳細
| RRC ID | 11001 |
|---|---|
| 著者 | Yen PH, Kiem PV, Nhiem NX, Tung NH, Quang TH, Minh CV, Kim JW, Choi EM, Kim YH. |
| タイトル | A new monoterpene glycoside from the roots of Paeonia lactiflora increases the differentiation of osteoblastic MC3T3-E1 cells. |
| ジャーナル | Arch Pharm Res |
| Abstract |
A new monoterpene glycoside, 6'-O-beta-D-glucopyranosylalbiflorin (1), and four known compounds; albiflorin (2), 6'-O-benzoylalbiflorin (3), paeoniflorin (4) and benzoyl paeoniflorin (5), were isolated from the methanolic extract of the roots of Paeonia lactiflora Pall.. Their chemical structures were completely elucidated using a combination of 2D NMR techniques (COSY, HMQC and HMBC) and HRESI-MS analyses. To investigate the bioactivities of these compounds, their effects on the differentiation of osteoblastic MC3T3-E1 cells were tested. Compound 1 (0.01-10 microM) significantly increased the alkaline phosphatase activity and nodules mineralization of MC3T3-E1 cells compared to those of the control (P<0.05). These results suggest that newly isolated compound 1 has a direct stimulatory effect on bone formation in vitro and may contribute to the prevention for osteoporosis. |
| 巻・号 | 30(10) |
| ページ | 1179-85 |
| 公開日 | 2007-10-1 |
| DOI | 10.1007/BF02980258 |
| PMID | 18038896 |
| MeSH | Alkaline Phosphatase / metabolism Animals Benzoates / pharmacology Bone Density Conservation Agents / chemistry Bone Density Conservation Agents / isolation & purification Bone Density Conservation Agents / pharmacology* Bridged-Ring Compounds / pharmacology Calcification, Physiologic / drug effects Cell Differentiation* Cell Line Dose-Response Relationship, Drug Glucosides / pharmacology Glycosides / chemistry Glycosides / isolation & purification Glycosides / pharmacology* Magnetic Resonance Spectroscopy Mice Molecular Structure Monoterpenes / chemistry Monoterpenes / isolation & purification Monoterpenes / pharmacology* Osteoblasts / drug effects* Osteoblasts / enzymology Paeonia* / chemistry Plant Extracts / pharmacology Plant Roots Spectrometry, Mass, Electrospray Ionization Vietnam |
| IF | 2.934 |
| 引用数 | 41 |
| WOS 分野 | CHEMISTRY, MEDICINAL PHARMACOLOGY & PHARMACY |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |