| RRC ID |
1104
|
| 著者 |
Jang MH, Kweon MN, Iwatani K, Yamamoto M, Terahara K, Sasakawa C, Suzuki T, Nochi T, Yokota Y, Rennert PD, Hiroi T, Tamagawa H, Iijima H, Kunisawa J, Yuki Y, Kiyono H.
|
| タイトル |
Intestinal villous M cells: an antigen entry site in the mucosal epithelium.
|
| ジャーナル |
Proc Natl Acad Sci U S A
|
| Abstract |
M cells located in the follicle-associated epithelium of Peyer's patches (PP) are shown to be the principal sites for the sampling of gut luminal antigens. Thus, PP have long been considered the gatekeepers of the mucosal immune system. Here, we report a distinct gateway for the uptake of gut bacteria: clusters of non-follicle-associated epithelium-associated Ulex europaeus agglutinin (UEA)-1(+) cells, which we have designated intestinal villous M cells. Interestingly, villous M cells are developed in various PP [or gut-associated lymphoid tissue (GALT)]-null mice, such as in utero lymphotoxin beta receptor (LTbetaR)-Ig-treated, lymphotoxin alpha (LTalpha)(-/-), tumor necrosis factor/LTalpha(-/-), and inhibition of differentiation 2 (Id2)(-/-) mice. Intestinal villous M cells have been observed to take up GFP-expressing Salmonella, Yersinia, and Escherichia coli-expressing invasin, as well as gut bacterial antigen for subsequent induction of antigen-specific immune responses. Thus, the identified villous M cells could be an alternative and PP-independent gateway for the induction of antigen-specific immune responses by means of the mucosal compartment.
|
| 巻・号 |
101(16)
|
| ページ |
6110-5
|
| 公開日 |
2004-4-20
|
| DOI |
10.1073/pnas.0400969101
|
| PII |
0400969101
|
| PMID |
15071180
|
| PMC |
PMC395931
|
| MeSH |
Animals
Antigens / immunology*
Bacterial Adhesion
Intestinal Mucosa / cytology*
Intestinal Mucosa / immunology
Intestinal Mucosa / microbiology
Intestinal Mucosa / ultrastructure
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Microscopy, Electron
Peyer's Patches / immunology
Salmonella typhimurium / physiology
|
| IF |
9.412
|
| 引用数 |
321
|
|
WOS 分野
|
IMMUNOLOGY
|
| リソース情報 |
| 病原微生物 |
|
