Reference - Detail
| RRC ID | 11082 |
|---|---|
| Author | Gubb D, Sanz-Parra A, Barcena L, Troxler L, Fullaondo A. |
| Title | Protease inhibitors and proteolytic signalling cascades in insects. |
| Journal | Biochimie |
| Abstract |
Proteolytic signalling cascades control a wide range of physiological responses. In order to respond rapidly, protease activity must be maintained at a basal level: the component zymogens must be sequentially activated and actively degraded. At the same time, signalling cascades must respond precisely: high target specificity is required. The insects have a wide range of trapping- and tight-binding protease inhibitors, which can regulate the activity of individual proteases. In addition, the interactions between component proteases of a signalling cascade can be modified by serine protease homologues. The suicide-inhibition mechanism of serpin family inhibitors gives rapid turnover of both protease and inhibitor, but target specificity is inherently broad. Similarly, the TEP/macroglobulins have extremely broad target specificity, which suits them for roles as hormone transport proteins and sensors of pathogenic virulence factors. The tight-binding inhibitors, on the other hand, have a lock-and-key mechanism capable of high target specificity. In addition, proteins containing multiple tight-binding inhibitory domains may act as scaffolds for the assembly of signalling complexes. Proteolytic cascades regulated by combinations of different types of inhibitor could combine the rapidity of suicide-inhibitors with the specificity lock-and-key inhibitors. This would allow precise control of physiological responses and may turn out to be a general rule. |
| Volume | 92(12) |
| Pages | 1749-59 |
| Published | 2010-12-1 |
| DOI | 10.1016/j.biochi.2010.09.004 |
| PII | S0300-9084(10)00320-2 |
| PMID | 20850496 |
| MeSH | Animals Insect Proteins / metabolism* Insecta / metabolism* Macroglobulins / metabolism Peptide Hydrolases / metabolism* Protease Inhibitors / classification Protease Inhibitors / metabolism* Serpins / metabolism Signal Transduction* |
| IF | 3.413 |
| Times Cited | 48 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Resource | |
| Drosophila | 4804R-1 8137R-3 4804R-1 9334R-3 9460R-3 127172R-1 10913R-1 12807R-1 6687R-1 1342R-1 |