Reference - Detail
|Author||Babcock DT, Landry C, Galko MJ.|
|Title||Cytokine signaling mediates UV-induced nociceptive sensitization in Drosophila larvae.|
BACKGROUND:Heightened nociceptive (pain) sensitivity is an adaptive response to tissue damage and serves to protect the site of injury. Multiple mediators of nociceptive sensitization have been identified in vertebrates, but the complexity of the vertebrate nervous system and tissue-repair responses has hindered identification of the precise roles of these factors.
RESULTS:Here we establish a new model of nociceptive sensitization in Drosophila larvae, in which UV-induced tissue damage alters an aversive withdrawal behavior. We find that UV-treated larvae develop both thermal hyperalgesia, manifested as an exaggerated response to noxious thermal stimuli, and thermal allodynia, a responsiveness to subthreshold thermal stimuli that are not normally perceived as noxious. Allodynia is dependent upon a tumor necrosis factor (TNF) homolog, Eiger, released from apoptotic epidermal cells, and the TNF receptor, Wengen, expressed on nociceptive sensory neurons.
CONCLUSIONS:These results demonstrate that cytokine-mediated nociceptive sensitization is conserved across animal phyla and set the stage for a sophisticated genetic dissection of the cellular and molecular alterations responsible for development of nociceptive sensitization in sensory neurons.
|MeSH||Animals Apoptosis / physiology Behavior, Animal / physiology Caspases / metabolism Drosophila / anatomy & histology Drosophila / physiology* Epidermis / pathology Epidermis / radiation effects Hyperalgesia / metabolism* Larva / anatomy & histology Larva / physiology* Larva / radiation effects Nociceptors / metabolism Pain / metabolism* Pain / physiopathology Pain Threshold Signal Transduction / physiology* Tumor Necrosis Factor-alpha / metabolism* Ultraviolet Rays|
|WOS Category||BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY|