論文 - 詳細
| RRC ID | 11152 |
|---|---|
| 著者 | Drapeau MD, Cyran SA, Viering MM, Geyer PK, Long AD. |
| タイトル | A cis-regulatory sequence within the yellow locus of Drosophila melanogaster required for normal male mating success. |
| ジャーナル | Genetics |
| Abstract |
Drosophila melanogaster males perform a courtship ritual consisting of a series of dependent fixed-action patterns. The yellow (y) gene is required for normal male courtship behavior and subsequent mating success. To better characterize the requirement for y in the manifestation of innate male sexual behavior, we measured the male mating success (MMS) of 12 hypomorphic y mutants and matched-outbred-background controls using a y+ rescue element on a freely segregating minichromosome. We found that 4 hypomorphs significantly reduced MMS to varying degrees. Reduced MMS was largely independent of adult pigmentation patterns. These mutations defined a 300-bp regulatory region upstream of the transcription start, the mating-success regulatory sequence (MRS), whose function is required for normal MMS. Visualization of gene action via GFP and a Yellow antibody suggests that the MRS directs y transcription in a small number of cells in the third instar CNS, the developmental stage previously implicated in the role of y with regard to male courtship behavior. The presence of Yellow protein in these cells positively correlates with MMS in a subset of mutants. The MRS contains a regulatory sequence controlling larval pigmentation and a 35-bp sequence that is highly conserved within the genus Drosophila and is predicted to bind known transcription factors. |
| 巻・号 | 172(2) |
| ページ | 1009-30 |
| 公開日 | 2006-2-1 |
| DOI | 10.1534/genetics.105.045666 |
| PII | genetics.105.045666 |
| PMID | 16272418 |
| PMC | PMC1456202 |
| MeSH | Animals Base Sequence Courtship Crosses, Genetic Drosophila Proteins / genetics* Drosophila Proteins / physiology Gene Expression Regulation, Developmental / physiology* Genetic Markers Genetic Variation Larva / genetics Male Molecular Sequence Data Pigmentation / genetics Sexual Behavior, Animal / physiology* Transcription Factors / physiology |
| IF | 4.015 |
| 引用数 | 43 |
| WOS 分野 | GENETICS & HEREDITY |
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