RRC ID 1117
Author Ogawa M, Yoshimori T, Suzuki T, Sagara H, Mizushima N, Sasakawa C.
Title Escape of intracellular Shigella from autophagy.
Journal Science
Abstract The degradation of undesirable cellular components or organelles, including invading microbes, by autophagy is crucial for cell survival. Here, Shigella, an invasive bacteria, was found to be able to escape autophagy by secreting IcsB by means of the type III secretion system. Mutant bacteria lacking IcsB were trapped by autophagy during multiplication within the host cells. IcsB did not directly inhibit autophagy. Rather, Shigella VirG, a protein required for intracellular actin-based motility, induced autophagy by binding to the autophagy protein, Atg5. In nonmutant Shigella, this binding is competitively inhibited by IcsB binding to VirG.
Volume 307(5710)
Pages 727-31
Published 2005-2-4
DOI 10.1126/science.1106036
PII 1106036
PMID 15576571
MeSH Animals Autophagy* Autophagy-Related Protein 5 Bacterial Proteins / genetics Bacterial Proteins / metabolism* Cell Line DNA-Binding Proteins / metabolism* Humans Mice Mice, Knockout Microscopy, Electron Microtubule-Associated Proteins / metabolism Phagosomes / metabolism Phagosomes / microbiology* Phagosomes / ultrastructure Protein Binding Recombinant Fusion Proteins / metabolism Shigella flexneri / genetics Shigella flexneri / growth & development Shigella flexneri / metabolism Shigella flexneri / pathogenicity* Transcription Factors / metabolism*
IF 41.058
Times Cited 511
Pathogenic microorganisms ?