| RRC ID |
112
|
| 著者 |
Sato Y, Endo H, Ajiki T, Hakamata Y, Okada T, Murakami T, Kobayashi E.
|
| タイトル |
Establishment of Cre/LoxP recombination system in transgenic rats.
|
| ジャーナル |
Biochem Biophys Res Commun
|
| Abstract |
The rat has offered an important animal model in biomedical research including surgical procedure. However, advanced genetic manipulation has progressed less far in the rat than in the mouse. Here we report the Cre/LoxP transgenic rat system, demonstrating conditional chromosomal translocation both in the fertilization and adult stage, spatio-temporal gene controlling by catheter-based adenoviral gene transfer, and muscular fusion events in the limb transplant. Taking advantage of the larger body size of the rat than the mouse, this rat system provides a potential value to evaluate biomedical and therapeutic significance for gene therapy and regenerative medicine.
|
| 巻・号 |
319(4)
|
| ページ |
1197-202
|
| 公開日 |
2004-7-9
|
| DOI |
10.1016/j.bbrc.2004.04.204
|
| PII |
S0006291X04008101
|
| PMID |
15194493
|
| MeSH |
Animals
Animals, Genetically Modified*
Animals, Newborn
Gene Expression Regulation
Gene Transfer Techniques*
Genes, Reporter
Genetic Therapy
Genetic Vectors / genetics
Genetic Vectors / metabolism
Humans
Male
Mice
Muscle, Skeletal / cytology
Muscle, Skeletal / physiology
Pancreas / cytology
Pancreas / metabolism
Promoter Regions, Genetic
Rats
Rats, Wistar
Recombination, Genetic*
Tissue Transplantation
Transgenes
|
| IF |
2.985
|
| 引用数 |
24
|
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| ラット |
W-Tg(CAG-cre)81Jmsk(strainID=534) |
