RRC ID 112
Author Sato Y, Endo H, Ajiki T, Hakamata Y, Okada T, Murakami T, Kobayashi E.
Title Establishment of Cre/LoxP recombination system in transgenic rats.
Journal Biochem. Biophys. Res. Commun.
Abstract The rat has offered an important animal model in biomedical research including surgical procedure. However, advanced genetic manipulation has progressed less far in the rat than in the mouse. Here we report the Cre/LoxP transgenic rat system, demonstrating conditional chromosomal translocation both in the fertilization and adult stage, spatio-temporal gene controlling by catheter-based adenoviral gene transfer, and muscular fusion events in the limb transplant. Taking advantage of the larger body size of the rat than the mouse, this rat system provides a potential value to evaluate biomedical and therapeutic significance for gene therapy and regenerative medicine.
Volume 319(4)
Pages 1197-202
Published 2004-7-9
DOI 10.1016/j.bbrc.2004.04.204
PII S0006291X04008101
PMID 15194493
MeSH Animals Animals, Genetically Modified* Animals, Newborn Gene Expression Regulation Gene Transfer Techniques* Genes, Reporter Genetic Therapy Genetic Vectors / genetics Genetic Vectors / metabolism Humans Male Mice Muscle, Skeletal / cytology Muscle, Skeletal / physiology Pancreas / cytology Pancreas / metabolism Promoter Regions, Genetic Rats Rats, Wistar Recombination, Genetic* Tissue Transplantation Transgenes
IF 2.559
Times Cited 21
Rats W-Tg(CAG-cre)81Jmsk(strainID=534)