論文 - 詳細
| RRC ID | 112 |
|---|---|
| 著者 | Sato Y, Endo H, Ajiki T, Hakamata Y, Okada T, Murakami T, Kobayashi E. |
| タイトル | Establishment of Cre/LoxP recombination system in transgenic rats. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
The rat has offered an important animal model in biomedical research including surgical procedure. However, advanced genetic manipulation has progressed less far in the rat than in the mouse. Here we report the Cre/LoxP transgenic rat system, demonstrating conditional chromosomal translocation both in the fertilization and adult stage, spatio-temporal gene controlling by catheter-based adenoviral gene transfer, and muscular fusion events in the limb transplant. Taking advantage of the larger body size of the rat than the mouse, this rat system provides a potential value to evaluate biomedical and therapeutic significance for gene therapy and regenerative medicine. |
| 巻・号 | 319(4) |
| ページ | 1197-202 |
| 公開日 | 2004-7-9 |
| DOI | 10.1016/j.bbrc.2004.04.204 |
| PII | S0006291X04008101 |
| PMID | 15194493 |
| MeSH | Animals Animals, Genetically Modified* Animals, Newborn Gene Expression Regulation Gene Transfer Techniques* Genes, Reporter Genetic Therapy Genetic Vectors / genetics Genetic Vectors / metabolism Humans Male Mice Muscle, Skeletal / cytology Muscle, Skeletal / physiology Pancreas / cytology Pancreas / metabolism Promoter Regions, Genetic Rats Rats, Wistar Recombination, Genetic* Tissue Transplantation Transgenes |
| IF | 2.985 |
| 引用数 | 24 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ラット | W-Tg(CAG-cre)81Jmsk(strainID=534) |