| RRC ID |
11202
|
| Author |
Asaduzzaman SM, Nagao J, Iida H, Zendo T, Nakayama J, Sonomoto K.
|
| Title |
Nukacin ISK-1, a bacteriostatic lantibiotic.
|
| Journal |
Antimicrob Agents Chemother
|
| Abstract |
We determined the mode of action of nukacin ISK-1. It did not cause membrane potential dissipation or the efflux of ATP or K(+) ions from the cells of a sensitive bacterial strain; however, it blocked the membrane depolarization activity of nisin. Nukacin ISK-1-treated cells had single arrangements of cells without the formation of a complete septum. A remarkable reduction in cell wall width was also observed, but cytoplasmic content was unaffected. We concluded that nukacin ISK-1 is bacteriostatic.
|
| Volume |
53(8)
|
| Pages |
3595-8
|
| Published |
2009-8-1
|
| DOI |
10.1128/AAC.01623-08
|
| PII |
AAC.01623-08
|
| PMID |
19506061
|
| PMC |
PMC2715603
|
| MeSH |
Anti-Bacterial Agents / pharmacology
Bacillus subtilis / drug effects
Bacillus subtilis / metabolism
Bacillus subtilis / ultrastructure
Bacteriocins / chemistry
Bacteriocins / pharmacology*
Membrane Potentials / drug effects
Microscopy, Electron, Transmission
Models, Biological
Nisin / chemistry
Nisin / pharmacology
|
| IF |
4.904
|
| Times Cited |
28
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
MICROBIOLOGY
|
| Resource |
| General Microbes |
JCM 1465
JCM 1157 |
