| RRC ID |
11206
|
| 著者 |
Minami M, Ando T, Okamoto A, Sasaki N, Ohkura T, Torii K, Hasegawa T, Ohta M, Goto H.
|
| タイトル |
Seroprevalence of Fusobacterium varium in ulcerative colitis patients in Japan.
|
| ジャーナル |
FEMS Immunol Med Microbiol
|
| Abstract |
The etiology of ulcerative colitis (UC) is unknown, while an exacerbating factor of this disease is associated with infectious agents. Recently, Fusobacterium varium has been found in the mucosa of a significant number of patients with UC. The aim of this study was to estimate the prevalence of F. varium infection based on serology, evaluate the relationship between F. varium seropositivity and UC, and determine the clinical characteristics of infected UC individuals. Seropositive patients were determined by immunoblotting with F. varium ATCC 8501 antigen. We also identified cross-reactive protein spots by peptide mass mapping analysis. These protein spots showed putative caseinolytic protease protein, putative translation elongation factor G, and putative enolase. Immunoblotting with F. varium antigen revealed signals with sera from 45 (40.2%) of the 112 UC patients and 20 (15.6%) of the 128 healthy controls, respectively (P<0.01). In terms of disease activity, seropositive UC patients were more likely to have clinically severe disease than seronegative UC patients. Disease location in seropositive patients was more extensive than the seronegative patients. In conclusion, F. varium is a predominant infection in the UC population and is a potential pathogen of UC.
|
| 巻・号 |
56(1)
|
| ページ |
67-72
|
| 公開日 |
2009-6-1
|
| DOI |
10.1111/j.1574-695X.2009.00550.x
|
| PMID |
19484811
|
| MeSH |
Adolescent
Adult
Aged
Animals
Antibodies, Bacterial / blood
Colitis, Ulcerative / blood
Colitis, Ulcerative / complications*
Colitis, Ulcerative / immunology
Female
Fusobacterium / immunology*
Fusobacterium Infections / complications*
Fusobacterium Infections / epidemiology*
Fusobacterium Infections / immunology
Humans
Japan / epidemiology
Male
Mice
Mice, Inbred BALB C
Middle Aged
Seroepidemiologic Studies
Severity of Illness Index
|
| 引用数 |
14
|
|
WOS 分野
|
INFECTIOUS DISEASES
MICROBIOLOGY
IMMUNOLOGY
|
| リソース情報 |
| 一般微生物 |
JCM 3721
JCM 3722
JCM 3723 |
