| RRC ID |
11268
|
| Author |
Kidokoro K, Ito K, Ogoyi DO, Abe H, Mita K, Kadono-Okuda K.
|
| Title |
Non-susceptibility genes to Bombyx densovirus type 1, Nid-1 and nsd-1, affect distinct steps of the viral infection pathway.
|
| Journal |
J Invertebr Pathol
|
| Abstract |
In the silkworm Bombyx mori, densovirus type 1 (BmDNV-1) replicates only in the midgut and causes fatal disease. Resistance to BmDNV-1 is determined by two genes, nsd-1 and Nid-1, respectively. Neither of them has been identified yet. We investigated the viral transcript by RT-PCR in inoculated silkworms carrying different sets of nsd-1 and Nid-1 genotype. BmDNV-1 transcript was not detected in nsd-1-carrying strains irrespective of existence of Nid-1 but clearly detected in strains carrying Nid-1 without nsd-1. The result suggests that nsd-1 blocks early step of infection. On the other hand, Nid-1 does not block cell and nucleus entry and viral transcription in nuclei but blocks later step in the viral infection cycle.
|
| Volume |
103(1)
|
| Pages |
79-81
|
| Published |
2010-1-1
|
| DOI |
10.1016/j.jip.2009.10.006
|
| PII |
S0022-2011(09)00217-1
|
| PMID |
19836396
|
| MeSH |
Animals
Bombyx / genetics*
Bombyx / virology*
Densovirus / pathogenicity*
Digestive System / virology
Genes, Insect*
Genetic Predisposition to Disease / genetics*
Genotype
Insect Viruses / pathogenicity
|
| IF |
2.074
|
| Times Cited |
9
|
|
WOS Category
|
ZOOLOGY
|
| Resource |
| Silkworms |
n30 |
