| RRC ID |
11279
|
| 著者 |
Tanaka H, Sagisaka A, Nakajima Y, Fujita K, Imanishi S, Yamakawa M.
|
| タイトル |
Correlation of differential expression of silkworm antimicrobial Peptide genes with different amounts of rel family proteins and their gene transcriptional activity.
|
| ジャーナル |
Biosci Biotechnol Biochem
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| Abstract |
In the silkworm, Bombyx mori, antimicrobial peptide (AMP) genes are upregulated in the larval fat body by injection of bacteria and peptidoglycans (PGNs). The DAP-type PGN from Escherichia coli and Bacillus subtilis exhibited stronger elicitor activity for expression of AMP genes in B. mori than Lys-type PGN from Staphylococcus aureus, suggesting that differences in bacterial influence on the induction levels of these genes depend on the differences in types of PGN. BmRelish1 mRNA was more abundant than BmRel mRNAs in the larval fat bodies. Moreover, the ability of the BmRelish1 active form to enhance the promoter activity of AMP genes was higher than that of BmRels. The difference was related to the binding affinity of Rel family proteins to kappaB sites. Our results suggest that different amounts and different transcriptional activities of Rel family proteins result in differential activation of AMP genes by PGN type and bacterium species.
|
| 巻・号 |
73(3)
|
| ページ |
599-606
|
| 公開日 |
2009-3-23
|
| DOI |
10.1271/bbb.80685
|
| PII |
JST.JSTAGE/bbb/80685
|
| PMID |
19270376
|
| MeSH |
Animals
Antimicrobial Cationic Peptides / genetics*
Bacteria / chemistry
Bombyx / genetics*
Diaminopimelic Acid / chemistry
Gene Expression Regulation* / drug effects
Insect Proteins / genetics*
Insect Proteins / metabolism
Lysine / chemistry
NF-kappa B / metabolism
Peptidoglycan / chemistry
Peptidoglycan / pharmacology
Promoter Regions, Genetic
RNA, Messenger / genetics
RNA, Messenger / metabolism
Transcription, Genetic*
|
| IF |
1.516
|
| 引用数 |
20
|
|
WOS 分野
|
FOOD SCIENCE & TECHNOLOGY
CHEMISTRY, APPLIED
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| カイコ |
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