Reference - Detail
|Author||Kageyama A, Hoshino Y, Yazawa K, Poonwan N, Takeshita N, Maki S, Mikami Y.|
|Title||Nocardia cyriacigeorgica is a significant pathogen responsible for nocardiosis in Japan and Thailand.|
Nocardia cyriacigeorgica is a recently described species. During routine diagnostic testing of 121 clinical isolates, we found that about one fourth of the strains from Japan (19 isolates) and Thailand (8 isolates), which were identified in our laboratories as N. asteroides, in fact belong to N. cyriacigeorgica. To our knowledge, this is the first report of infection due to N. cyriacigeorgica in Japan and Thailand, and the third report of infection anywhere in the world. Although N. cyriacigeorgica is usually differentiated from other Nocardia species by utilization of glucose and gluconate, we found that it can also be differentiated by a characteristic synergistic effect between imipenem (IPM) and tobramycin (TOB).
|MeSH||Adult Aged Aged, 80 and over Anti-Bacterial Agents / pharmacology Drug Synergism Female Humans Imipenem / pharmacology Japan Male Microbial Sensitivity Tests Middle Aged Nocardia / classification Nocardia / drug effects Nocardia / genetics Nocardia / isolation & purification* Nocardia Infections / diagnosis* Phylogeny Polymerase Chain Reaction RNA, Bacterial / genetics RNA, Ribosomal, 16S / genetics Species Specificity Thailand Tobramycin / pharmacology|
|Pathogenic microorganisms||IFM 0187 IFM 0236 IFM 0237 IFM 0239 IFM 0262 IFM 0280 IFM 0283 IFM 0284 IFM 0290 IFM 0319 IFM 0333 IFM 0411 IFM 0421 IFM 0438 IFM 0457 IFM 0464 IFM 0543 IFM 0552 IFM 0624 IFM 0659 IFM 0665 IFM 0788 IFM 0849 IFM 0851 IFM 0873 IFM 0913 IFM 0960 IFM 0978 IFM 0991 IFM 10001 IFM 10024 IFM 10028 IFM 10029 IFM 10063 IFM 10082 IFM 10086 IFM 10147 IFM 10174 IFM 10175 IFM 10176 IFM 10177 IFM 10199 IFM 10221 IFM 10226 IFM 10227 IFM 10235 IFM 10270 IFM 10318 IFM 10366|