論文 - 詳細
| RRC ID | 11546 |
|---|---|
| 著者 | Kanuka H, Kuranaga E, Takemoto K, Hiratou T, Okano H, Miura M. |
| タイトル | Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development. |
| ジャーナル | EMBO J |
| Abstract |
Caspases are well known for their role in the execution of apoptotic programs, in which they cleave specific target proteins, leading to the elimination of cells, and for their role in cytokine maturation. In this study, we identified a novel substrate, which, through cleavage by caspases, can regulate Drosophila neural precursor development. Shaggy (Sgg)46 protein, an isoform encoded by the sgg gene and essential for the negative regulation of Wingless signaling, is cleaved by the Dark-dependent caspase. This cleavage converts it to an active kinase, which contributes to the formation of neural precursor (sensory organ precursor (SOP)) cells. Our evidence suggests that caspase regulation of the wingless pathway is not associated with apoptotic cell death. These results imply a novel role for caspases in modulating cell signaling pathways through substrate cleavage in neural precursor development. |
| 巻・号 | 24(21) |
| ページ | 3793-806 |
| 公開日 | 2005-11-2 |
| DOI | 10.1038/sj.emboj.7600822 |
| PII | 7600822 |
| PMID | 16222340 |
| PMC | PMC1276714 |
| MeSH | Animals Caspases / metabolism* Cell Death Cell Differentiation Drosophila Proteins / metabolism* Drosophila melanogaster / cytology* Drosophila melanogaster / physiology* Glycogen Synthase Kinase 3 / metabolism* Glycogen Synthase Kinase 3 beta Neurons / cytology Sense Organs / cytology Signal Transduction |
| IF | 9.889 |
| 引用数 | 73 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#119559 DGRC#119560 |