RRC ID 1157
Author Unno H, Kamei K, Honda A, Nishimura K, Kuriyama T.
Title A murine model of pulmonary basidiomycosis by Schizophyllum commune.
Journal J. Infect. Chemother.
Abstract Schizophyllum commune has recently emerged as a causative agent of human mycosis, but the details of its virulence are not yet known. To elucidate the pathogenicity of S. commune, a murine model of invasive pulmonary infection was established. ICR mice, not immunosuppressed or immunosuppressed by cortisone acetate, were infected with S. commune by intratracheal inoculation with agar beads containing the basidiospores. All immunosuppressed mice died within 2 weeks. Pathology examination revealed massive mycelial invasion into the lungs, penetration into adjacent vessels, and systemic dissemination, suggesting much higher virulence of this fungus than was previously estimated. This is the first murine model of pulmonary infection by S. commune, which we believe can be of assistance during subsequent investigations of this infection.
Volume 11(3)
Pages 136-40
Published 2005-6
DOI 10.1007/s10156-005-0382-2
PII S1341-321X(05)70996-X
PMID 15990977
MeSH Animals Blood Vessels / microbiology Blood Vessels / pathology Disease Models, Animal Female Immunocompromised Host Lung / blood supply Lung / microbiology Lung / pathology Lung Diseases, Fungal / immunology Lung Diseases, Fungal / microbiology Lung Diseases, Fungal / pathology* Mice Mice, Inbred ICR Schizophyllum*
IF 1.539
Pathogenic microorganisms IFM 47009